BrdU (5-Bromo-2′-deoxyuridine)

(HB0979)
Technical documents: SDS CoA Datasheet

Product overview

Name BrdU (5-Bromo-2′-deoxyuridine)
Description Thymidine analog. Widely used to identify proliferating cells, enhances Yamanaka factor reprogramming
Biological description

Thymidine analog which is incorporated into DNA during DNA replication (during S-phase of cell cycle). 


BrdU is used to identify proliferating cells. Labels cell lines and primary cell cultures in vitro and also cells in vivo. 


Widely used to study adult neurogenesis. Can be used in combination with neuron specific markers such as NeuN to identify newly formed neurons.

Frequently used to label and fate-map dividing cells in neural stem cell biology.


Alternative names 5-BrdU, 5-bromo-2'-deoxyuridine, Broxuridine
Purity >98%
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (50mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 5-Bromo-2-deoxyuridine
Molecular Weight 307.1
Chemical structure Product image
Molecular Formula C9H11BrN2O5
CAS Number 59-14-3
PubChem identifier 6035
SMILES C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Br)CO)O
Source Synthetic
InChi InChI=1S/C9H11BrN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChiKey WOVKYSAHUYNSMH-RRKCRQDMSA-N
MDL number MFCD00006529
Appearance White solid

References for BrdU (5-Bromo-2′-deoxyuridine)

References are publications that support the biological activity of the product
  • Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors.

    Russo A et al (1984) Cancer Res 44(4) : 1702-5.
  • Neurogenesis in the adult human hippocampus.

    Eriksson PS et al (1998) Nat Med 4(11) : 1313-7.
  • The dark side of BrdU in neural stem cell biology: detrimental effects on cell cycle, differentiation and survival.

    Lehner B et al (2011) Cell Tissue Res 345(3) : 313-28.