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Images ZD 7288 product vial image | Hello Bio
ZD 7288 product vial image | Hello Bio Biological Data Biological description Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC50 = 15.0 µM).
Modulates sino-atrial node function; blocks the hyperpolarization-activated inward current If and inhibits Ih in central neurons.
Also inhibits Na+ currents in dorsal root ganglion neurons (IC50 = 1.17 µM).
Blocks long term potentiation (LTP) induction and displays anxiolytic properties.
Also increases doubling time of embryonic stem cells (ESCs) and modulates differentiation outcomes. Active in vivo .
Solubility & Handling Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
Chemical structure
Molecular Formula C15 H21 ClN4
PubChem identifier 123983
SMILES CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
InChi InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
InChiKey DUWKUHWHTPRMAP-UHFFFAOYSA-N
References for ZD 7288 References are publications that support the biological activity of the product
ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner. Omelyanenko et al (2016) Springerplus 16 : 5:41 Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze. Yeung M et al (2013) Hippocampus 23(4) : 278-86. Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents? Wu X et al (2012) Channels (Austin) 6(6) : 438-42. Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells. BoSmith RE et al (1993) Br J Pharmacol 110(1) : 343-9.
Publications
These publications cite the use of ZD 7288 purchased from Hello Bio:
Alpha-synuclein aggregates increase the conductance of substantia nigra dopamine neurons, an effect partly reversed by the KATP channel inhibitor glibenclamide Hill et al (2020) eNeuro : doi: 10.1523/ENEURO.0330-20.2020 Ke Action in the In Vitro Cortical Slice Is Mitigated by Potassium Channel Blockade. Voss et al (2018) Anesthesiology doi: 10.1097 : /ALN.0000000000002147. Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons. Kurowski et al (2018) Front Cell Neurosci. : 12:93 Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β1-Adrenergic Receptors and HCN Channels. Grzelka et al (2017) Front Cell Neurosci. 11:341 : 2
HCN channel blocker. Modulates sino-atrial node function.
![ZD 7288 [133059-99-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1152.png "ZD 7288 [133059-99-1]")
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