Selective mGlu5 receptor agonist which shows no activity at mGlu1. Potentiates NMDA-induced depolarizations in rat hippocampal slices. Active in vivo. Water soluble CHPG sodium salt also available.
Solubility & Handling
Storage instructions
+4°C (desiccate)
Solubility overview
Soluble in 0.1M NaOH (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Activation of mGluR5 attenuates NMDA-induced neurotoxicity through disruption of the NMDAR-PSD-95 complex and preservation of mitochondrial function in differentiated PC12 cells.
Dai SH et al (2014) Int J Mol Sci 15(6) : 10892-907.
Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices.
(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
Doherty AJ et al (1997) Neuropharmacology 36(2) : 265-7.
![(R,S)-CHPG [170846-74-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0033.png "(R,S)-CHPG [170846-74-9]")
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