Product overview

Name (R,S)-CHPG
Alternative names (R,S)-2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
Purity >98%
Description Selective mGlu5 agonist
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Biological Data

Biological description

Selective mGlu5 receptor agonist which shows no activity at mGlu1. Potentiates NMDA-induced depolarizations in rat hippocampal slices. Active in vivo. Water soluble CHPG sodium salt also available.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in 0.1M NaOH (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name (R,S)-2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
Molecular Weight 201.61
Chemical structure (R,S)-CHPG  [170846-74-9] Chemical Structure
Molecular Formula C8H8NO3Cl
CAS Number 170846-74-9
PubChem identifier 3645780
Source Synthetic
InChi InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
MDL number MFCD01321059
Appearance Off-white solid

References for (R,S)-CHPG

References are publications that support the biological activity of the product
  • Activation of mGluR5 attenuates NMDA-induced neurotoxicity through disruption of the NMDAR-PSD-95 complex and preservation of mitochondrial function in differentiated PC12 cells.

    Dai SH et al (2014) Int J Mol Sci 15(6) : 10892-907.
  • The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway.

    Chen T et al (2012) Int J Mol Med 29(4) : 630-6.
  • Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices.

    Fazal A et al (2003) J Neurochem 86(6) : 1346-58.
  • (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.

    Doherty AJ et al (1997) Neuropharmacology 36(2) : 265-7.

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