(R,S)-CHPG sodium salt product vial image | Hello Bio
(R,S)-CHPG sodium salt product vial image | Hello Bio
Biological Data
Biological description
Selective mGlu5 receptor agonist which shows no activity at mGlu1. Potentiates NMDA-induced depolarizations in rat hippocampal slices. Active in vivo. Water soluble sodium salt.
References are publications that support the biological activity of the product
Activation of mGluR5 attenuates NMDA-induced neurotoxicity through disruption of the NMDAR-PSD-95 complex and preservation of mitochondrial function in differentiated PC12 cells.
Dai SH et al (2014) Int J Mol Sci 15(6) : 10892-907.
Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices.
(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
Doherty AJ et al (1997) Neuropharmacology 36(2) : 265-7.
![(R,S)-CHPG sodium salt [1303993-73-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0034.png "(R,S)-CHPG sodium salt [1303993-73-8]")
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