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(RS)-MCPG product vial image | Hello Bio
(RS)-MCPG product vial image | Hello Bio
Biological Data
| Biological description | Non-selective group I and II mGluR antagonist.
Also competitive antagonist of ACPD sensitive receptors.
Shows no effect on locomotor activity.
Water soluble (R,S)-MCPG sodium salt and (S)-MCPG sodium salt also available. (S)-MCPG also available. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in 0.1M NaOH (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (RS)-α-Methyl-4-carboxyphenylglycine |
| Chemical structure | ![(RS)-MCPG [146669-29-6] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "(RS)-MCPG [146669-29-6]") |
| Molecular Formula | C10H11NO4 |
| SMILES | CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N |
| InChi | InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) |
| InChiKey | DNCAZYRLRMTVSF-UHFFFAOYSA-N |
References for (RS)-MCPG
References are publications that support the biological activity of the product
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The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats.
Kim JH et al (1998) Neuropharmacology 37(2) : 189-97. -
MCPG antagonizes metabotropic glutamate receptors but not long-term potentiation in the hippocampus.
Manzoni OJ et al (1994) Eur J Neurosci 6(6) : 1050-4. -
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.
Eaton SA et al (1993) Eur J Pharmacol 244(2) : 195-7.
Non-selective group I and II mGluR antagonist
![(RS)-MCPG [146669-29-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0037.png "(RS)-MCPG [146669-29-6]")
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