Recombinant rat CDNF protein

(HB8498)
Technical documents: Datasheet

Product overview

Name Recombinant rat CDNF protein
Alternative names Recombinant Rat Cerebral Dopamine Neurotrophic Factor, Cerebral neurotrophic factor, ARMET-like protein 1, Arginine-rich protein mutated in early stage tumors-like 1, Conserved neurotrophic factor, Cdnf, Armetl1.
Purity >97%
Description Rat CDNF protein
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Biological Data

Application notes Enhances neurite outgrowth of E16-E18 rat embryonic cortical neurons when immobilized at 5-25 µg/mL on a nitrocellulose-coated microplate.

Solubility & Handling

Solubility overview To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 100μg/ml, which can then be diluted to make a working solution
Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >97%
UniProt ID P0C5I0
Source E. Coli.
Structure image  Chemical Structure
Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a 0.2μm filtered solution in PBS (pH 7.4)

References for Recombinant rat CDNF protein

References are publications that support the biological activity of the product
  • CDNF Protein Therapy in Parkinson's Disease

    Huttunen HJ et al (2019) Cell Transplant 28(4) : 349-366
  • Characterization of recombinant human brain-derived neurotrophic factor variants

    Sunasara KM et al (1999) Arch Biochem Biophys 372(2) : 248-60
  • Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery

    Pardridge WM et al (1994) Pharm Res 11(5) : 738-46

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