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Images QX 314 bromide: Scientist Approved
QX 314 bromide product vial image | Hello Bio
QX 314 bromide: Scientist Approved QX 314 bromide product vial image | Hello Bio Biological Data Biological description Membrane impermeable Na+ channel blocker. A quaternary derivative of lidocaine. Reduces amplitude of high threshold Ca2+ currents in CA1 neurons. Displays anesthetic properties. QX 314 chloride also available.
Solubility & Handling Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name N -(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
Chemical structure
Molecular Formula C16 H27 N2 OBr
PubChem identifier 9884487
SMILES CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-]
InChi InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
InChiKey DLHMKHREUTXMCH-UHFFFAOYSA-N
References for QX 314 bromide References are publications that support the biological activity of the product
Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. Talbot MJ et al (1996) J Neurophysiol 76(3) : 2120-4. Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells. Colling SB et al (1994) Neurosci Lett 172(1-2) : 73-96. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. Strichartz GR (1973) J Gen Physiol 62(1) : 37-57.
Publications
These publications cite the use of QX 314 bromide purchased from Hello Bio:
PTC-174, a positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits Yi F et al (2020) Neuropharmacology 25 : 107971 Push-pull regulation of exploratory behavior by two opposing hippocampal to prefrontal cortex pathways Sánchez-Bellot et al (2019) bioRxiv https://doi.org/10.1101/2019.12.18.880831 : doi
Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties Foggetti A et al (2019) Cell Rep : 3725-3732.e5 Postnatal Development of Neural Networks in the Healthy and Premature Brain Cross, C. (2018) University of Bristol Thesis : 1-308
Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory Lepennetier et al (2018) Front. Cell. Neurosci. https://doi.org/ : 10.3389/fncel.2018.00318
Membrane impermeable Na+ channel blocker
![QX 314 bromide [24003-58-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1029.png "QX 314 bromide [24003-58-5]")
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