Target

Selective M₃ receptor antagonist

5-HT antagonist. Also partial agonist at adrenergic and dopaminergic receptors.

Partial α-adrenergic agonist, partial D₂ agonist and 5-HT antagonist

Peripheral dopamine D₂-like receptor antagonist

Potent, selective A₁ receptor inverse agonist

Group I / II mGlu antagonist

Selective mineralcorticoid receptor antagonist

D₂ receptor antagonist

Potent, selective, non-competitive mGlu₅ antagonist

Selective PAR₂ peptide antagonist