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FSLLRY-NH2

(HB3309)
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Product overview

Name FSLLRY-NH2
Biological description

FSLLRY-NH2 is a selective PAR2 peptide antagonist.

The peptide has been shown to block paclitaxel induced neuropathic pain in a dose- and time-dependent manner and to also inhibit itch-related behaviour in mice. Additionally, it prevents fibrosis in spontaneously hypertensive rats.

Active in vivo.

Alternative names FSLLRY, FS
Purity >95%
Description Selective PAR2 peptide antagonist
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >95%
Chemical name FSLLRY-NH2 (modifications: Tyr-6 = C-terminal amide)
Molecular Weight 796.97
Chemical structure FSLLRY-NH2 | [245329-02-6] Chemical Structure
Molecular Formula C39H60N10O8
Sequence (one letter) FSLLRY-NH2
Modifications Tyr-6 = C-terminal amide
CAS Number 245329-02-6
PubChem identifier 73352412
SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)N
InChiKey KMSCNWHRNILNRJ-JNRWAQIZSA-N

References for FSLLRY-NH2

References are publications that support the biological activity of the product

  • Protease-activated receptors and itch.

    Akiyama et al (2015) Handb Exp Pharmacol. 226 : 219-35
    Read more (PubMedID: 25861783)

  • Tryptase/Protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts.

    McLarty et al (2011) Hypertension 58(2) : 264-70
    Read more (PubMedID: 21730297)

  • Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.

    Chen et al (201 1) Neuroscience. 193 : 440-51
    Read more (PubMedID: 21763756)

3 Item(s)

Related Products
Grouped product items
Order: HB3309
Pack PriceQty
1mg
$77
Selective PAR2 peptide antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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