Product overview

Biological description

FSLLRY-NH2 is a selective PAR2 peptide antagonist.

The peptide has been shown to block paclitaxel induced neuropathic pain in a dose- and time-dependent manner and to also inhibit itch-related behaviour in mice. Additionally, it prevents fibrosis in spontaneously hypertensive rats.

Active in vivo.

Alternative names FSLLRY, FS
Purity >95%
Description Selective PAR2 peptide antagonist
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Chemical name FSLLRY-NH2 (modifications: Tyr-6 = C-terminal amide)
Molecular Weight 796.97
Chemical structure FSLLRY-NH2 | [245329-02-6] Chemical Structure
Molecular Formula C39H60N10O8
Sequence (one letter) FSLLRY-NH2
Modifications Tyr-6 = C-terminal amide
CAS Number 245329-02-6
PubChem identifier 73352412
SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)N

References for FSLLRY-NH2

References are publications that support the biological activity of the product
  • Protease-activated receptors and itch.

    Akiyama et al (2015) Handb Exp Pharmacol. 226 : 219-35
  • Tryptase/Protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts.

    McLarty et al (2011) Hypertension 58(2) : 264-70
  • Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.

    Chen et al (201 1) Neuroscience. 193 : 440-51

3 Item(s)