Technical documents: SDS CoA Datasheet

Product overview

Name Fenobam
Purity >99%
Description Potent, selective, non-competitive mGlu5 antagonist
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Biological Data

Biological description Potent, selective and non-competitive mGlu5 receptor antagonist. Acts at allosteric modulatory site (Kd values are 54 and 31 nM at rat and human mGlu5 receptors respectively). Shows inverse agonist properties on receptor basal activity (IC50 value = 84 nM). Displays analgesic, anxiolytic and antidepressant effects. Orally active.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea
Molecular Weight 266.69
Chemical structure Fenobam  [57653-26-6] Chemical Structure
Molecular Formula C11H11N4O2Cl
CAS Number 57653-26-6
PubChem identifier 162834
Source Synthetic
InChi InChI=1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18)
MDL number MFCD00868019
Appearance Yellow solid

References for Fenobam

References are publications that support the biological activity of the product
  • The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.

    Montana MC et al (2009) J Pharmacol Exp Ther 330(3) : 834-43.
  • Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction.

    Carroll FI (2008) Ann N Y Acad Sci 1141 : 221-32.
  • Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.

    Porter RH et al (2005) J Pharmacol Exp Ther 315(2) : 711-21.

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