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GBR 12909 dihydrochloride

(HB1812)
Publications (3)
Technical documents: SDS Datasheet
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Product overview

Name GBR 12909 dihydrochloride
Alternative names Vanoxerine
Purity >98%
Description Potent, competitive dopamine uptake inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (3) References (3) Frequently bought together
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Biological Data

Biological description Potent, competitive dopamine uptake inhibitor (Ki = 1 nM). Also a potent Kv11.1, and Na+ and Ca+ channel blocker (IC50 values are 0.8, 320 and 830 nM at hKv11.1, hICa,L and hNav1.5 respectively and σ receptor blocker). Shows variety of biological actions. Active in vivo.

Solubility & Handling

Solubility overview Soluble in water (25 mM, gentle warming) and in DMSO (50 mM)
Storage instructions Room temperature (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Molecular Weight 523.49
Chemical structure GBR 12909 dihydrochloride [67469-78-7] Chemical Structure
Molecular Formula C28H32F2N2O.2HCl
CAS Number 67469-78-7
PubChem identifier 104920
SMILES C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl
InChi InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
InChiKey MIBSKSYCRFWIRU-UHFFFAOYSA-N
MDL number MFCD00055193

References for GBR 12909 dihydrochloride

References are publications that support the biological activity of the product

  • Vanoxerine: cellular mechanism of a new antiarrhythmic.

    Lacerda AE et al (2010) J Cardiovasc Electrophysiol 21(3) : 301-10.
    Read more (PubMedID: 19817928)

  • Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery.

    Espaã±a RA et al (2008) Neuroscience 155(1) : 250-7.
    Read more (PubMedID: 18597947)

  • The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.

    Andersen PH (1989) Eur J Pharmacol 166(3) : 493-504.
    Read more (PubMedID: 2530094)

3 Item(s)

Publications
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These publications cite the use of GBR 12909 dihydrochloride purchased from Hello Bio:

  • A dynamic role for dopamine receptors in the control of mammalian spinal networks

    Sharples et al (2020) Sci Rep. : 10(1)
    PubMedID: 33009442

  • Dopaminergic control of postnatal mammalian spinal network function is predominantly inhibitory

    Sharples et al (2019) bioRxiv : https://doi.org/10.1101/715326

  • State-dependent neuromodulation of mammalian spinal networks

    Sharples et al (2018) University of Calgary : Thesis

3 Item(s)

Related Products
Grouped product items
Order: HB1812
Pack PriceQty
10mg
$107
50mg
$367
Potent, competitive dopamine uptake inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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