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Biological Data Biological description Potent, competitive dopamine uptake inhibitor (Ki = 1 nM). Also a potent Kv 11.1, and Na+ and Ca+ channel blocker (IC50 values are 0.8, 320 and 830 nM at hKv 11.1, hICa,L and hNav 1.5 respectively and σ receptor blocker). Shows variety of biological actions. Active in vivo .
Solubility & Handling Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (25 mM, gentle warming) and in DMSO (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 1-[2-[Bis -(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Chemical structure
Molecular Formula C28 H32 F2 N2 O.2HCl
PubChem identifier 104920
SMILES C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl
InChi InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
InChiKey MIBSKSYCRFWIRU-UHFFFAOYSA-N
References for GBR 12909 dihydrochloride References are publications that support the biological activity of the product
Vanoxerine: cellular mechanism of a new antiarrhythmic. Lacerda AE et al (2010) J Cardiovasc Electrophysiol 21(3) : 301-10. Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery. Espaã±a RA et al (2008) Neuroscience 155(1) : 250-7. The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. Andersen PH (1989) Eur J Pharmacol 166(3) : 493-504.
Publications
These publications cite the use of GBR 12909 dihydrochloride purchased from Hello Bio:
A dynamic role for dopamine receptors in the control of mammalian spinal networks Sharples et al (2020) Sci Rep. : 10(1) Dopaminergic control of postnatal mammalian spinal network function is predominantly inhibitory Sharples et al (2019) bioRxiv : https://doi.org/10.1101/715326
State-dependent neuromodulation of mammalian spinal networks Sharples et al (2018) University of Calgary : Thesis
Potent, competitive dopamine uptake inhibitor
![GBR 12909 dihydrochloride [67469-78-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1812.png "GBR 12909 dihydrochloride [67469-78-7]")
Understanding purity and quality - a guide for life scientists
