GBR 12909 dihydrochloride

Technical documents: SDS Datasheet

Product overview

Name GBR 12909 dihydrochloride
Alternative names Vanoxerine
Purity >98%
Description Potent, competitive dopamine uptake inhibitor
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Biological Data

Biological description Potent, competitive dopamine uptake inhibitor (Ki = 1 nM). Also a potent Kv11.1, and Na+ and Ca+ channel blocker (IC50 values are 0.8, 320 and 830 nM at hKv11.1, hICa,L and hNav1.5 respectively and σ receptor blocker). Shows variety of biological actions. Active in vivo.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (25 mM, gentle warming) and in DMSO (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Molecular Weight 523.49
Chemical structure GBR 12909 dihydrochloride  [67469-78-7] Chemical Structure
Molecular Formula C28H32F2N2O.2HCl
CAS Number 67469-78-7
PubChem identifier 104920
InChi InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
MDL number MFCD00055193

References for GBR 12909 dihydrochloride

References are publications that support the biological activity of the product
  • Vanoxerine: cellular mechanism of a new antiarrhythmic.

    Lacerda AE et al (2010) J Cardiovasc Electrophysiol 21(3) : 301-10.
  • Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery.

    Espaã±a RA et al (2008) Neuroscience 155(1) : 250-7.
  • The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.

    Andersen PH (1989) Eur J Pharmacol 166(3) : 493-504.

3 Item(s)

These publications cite the use of GBR 12909 dihydrochloride purchased from Hello Bio:
  • A dynamic role for dopamine receptors in the control of mammalian spinal networks

    Sharples et al (2020) Sci Rep. : 10(1)
    PubMedID: 33009442
  • Dopaminergic control of postnatal mammalian spinal network function is predominantly inhibitory

    Sharples et al (2019) bioRxiv :
  • State-dependent neuromodulation of mammalian spinal networks

    Sharples et al (2018) University of Calgary : Thesis

3 Item(s)