We are using MK801 in our research. We are very satisfied with the quality of this product.Verified customer, UCSD
(+)-MK 801 maleate does what it should! It is a very good product, delivered very rapidly.Verified customer, Research University Paris
...our first order with Hello Bio, has been satisfactory. The (+)-MK 801 Maleate has arrived in only some days and it was in perfect conditions.Verified customer, Universidad de La Laguna
Figure 1. (+)-MK 801 inhibition of evoked NMDAR mediated EPSCs in mouse cortical neuron
The NMDA receptor antagonist (+)-MK 801 is use-dependent and blocks NMDARs in their open conformation. (+)-MK 801 from Hello Bio fully abolishes evoked NMDAR currents at 10 µM rapidly upon repeated stimulations. At concentrations of 50 µM a more rapid receptor blockade was observed. For assay protocol, see #Protocol 1 in Application Notes below
Figure 2. (+)-MK 801 inhibition of evoked NMDAR mediated EPSCs in mouse cortical neuron
The NMDA receptor antagonist (+)-MK 801 is use-dependent and blocks NMDARs in their open conformation. (+)-MK 801 from Hello Bio fully abolishes evoked NMDAR currents at 10 µM rapidly upon repeated stimulations. At concentrations of 50 µM a more rapid receptor blockade was observed. For assay protocol, see #Protocol 1 in Application Notes below
(+)-MK 801 maleate: Scientist Approved
(+)-MK 801 maleate product vial image | Hello Bio
Figure 1. (+)-MK 801 inhibition of evoked NMDAR mediated EPSCs in mouse cortical neuron
The NMDA receptor antagonist (+)-MK 801 is use-dependent and blocks NMDARs in their open conformation. (+)-MK 801 from Hello Bio fully abolishes evoked NMDAR currents at 10 µM rapidly upon repeated stimulations. At concentrations of 50 µM a more rapid receptor blockade was observed. For assay protocol, see #Protocol 1 in Application Notes below
Figure 2. (+)-MK 801 inhibition of evoked NMDAR mediated EPSCs in mouse cortical neuron
The NMDA receptor antagonist (+)-MK 801 is use-dependent and blocks NMDARs in their open conformation. (+)-MK 801 from Hello Bio fully abolishes evoked NMDAR currents at 10 µM rapidly upon repeated stimulations. At concentrations of 50 µM a more rapid receptor blockade was observed. For assay protocol, see #Protocol 1 in Application Notes below
(+)-MK 801 maleate: Scientist Approved
(+)-MK 801 maleate product vial image | Hello Bio
Biological Data
Biological description
Potent, selective and non-competitive NMDA receptor antagonist (Kd = 37.2 nM). Approx 10-fold more potent than (-)-MK 801 maleate. Prevents calcium ion influx and long term potentiation induction. Shows anticonvulsant and neuroprotective properties.
Application notes
The NMDA receptor antagonist (+)-MK 801 is use-dependent and blocks NMDARs in their open conformation.
(+)-MK 801 from Hello Bio fully abolishes evoked NMDAR currents at 10 μM rapidly upon repeated stimulations (see Fig 1 above). At concentrations of 50 μM a more rapid receptor blockade was observed.
#Protocol 1: Evoked NMDA receptor currents
Whole cell voltage clamp recordings were obtained from layer V neurons of the mouse prelimbic cortex brain slice.
NMDA currents were evoked via a stimulating electrode placed in layers II/III and evoked by a single square (150 μs) pulse every 10 sec at a stimulus intensity that gave a reliable NMDA current.
Neurons were held at +40 mV to relieve NMDA currents from their voltage-dependent Mg2+ block.
NMDA currents were continually stimulated and recorded in response to continual bath applications of (+)-MK 801 until NMDA currents were completely abolished.
All NMDAR recordings were made in the presence of GABAA-R and AMPAR antagonists.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in water (25mM, gentle warming) and in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
The effects of dizocilpine maleate (MK-801), an antagonist of the N-methyl-D-aspartate receptor, on neurologic recovery and histopathology following complete cerebral ischemia in primates.
Lanier WL et al (1990) J Cereb Blood Flow Metab 10(2) : 252-61.
Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis
![(+)-MK 801 maleate [77086-22-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0004.png "(+)-MK 801 maleate [77086-22-7]")
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