Product overview

Name Methoxy-X04
Description Fluorescent amyloid β stain. BBB permeable.
Purity >98%
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Biological Data

Biological description

Methoxy-X04 is a blood-brain barrier (BBB) permeable fluorescent amyloid β marker which specifically binds to amyloid deposits in postmortem AD brain sections.

It can be used to stain amyloid beta plaques, tangles and cerebrovascular amyloid.

It shows in vitro binding affinity of Amyloid beta fibrils (Ki = 26.87 nM). The compound is active in vivo

Solubility & Handling

Storage instructions +4°C. Protect from light.
Solubility overview Soluble in DMSO (100 mM), and in ethanol (20 mM). Protect from light.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Chemical name 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
Molecular Weight 344.4
Chemical structure Methoxy-X04 [863918-78-9] Chemical Structure
Molecular Formula C23H20O3
CAS Number 863918-78-9
PubChem identifier 16049314
SMILES COC1=C(C=CC(=C1)/C=C/C2=CC=C(C=C2)O)/C=C/C3=CC=C(C=C3)O
Source Synthetic
InChi InChI=1S/C23H20O3/c1-26-23-16-19(3-2-17-6-12-21(24)13-7-17)5-11-20(23)10-4-18-8-14-22(25)15-9-18/h2-16,24-25H,1H3/b3-2+,10-4+
InChiKey FGYNZFHVGOFCMD-KHVHPYDTSA-N
Appearance Yellow solid

References for Methoxy-X04

References are publications that support the biological activity of the product
  • A Study of Amyloid-beta and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients

    Furcila D et al (2018) J Alzheimers Dis 64(2) : 417-435
  • Fibrillar amyloid plaque formation precedes microglial activation

    Jung CK et al (2015) PLoS One 10(3) : e0119768
  • Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

    Klunk WE et al (2002) J Neuropathol Exp Neurol 61(9) : 797-805