Product overview
| Name | Methoxy-X04 |
| Description | Fluorescent amyloid β stain. BBB permeable. |
| Purity | >98% |
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Biological Data
| Biological description | Methoxy-X04 is a blood-brain barrier (BBB) permeable fluorescent amyloid β marker which specifically binds to amyloid deposits in postmortem AD brain sections. It can be used to stain amyloid beta plaques, tangles and cerebrovascular amyloid. It shows in vitro binding affinity of Amyloid beta fibrils (Ki = 26.87 nM). The compound is active in vivo |
Solubility & Handling
| Storage instructions | +4°C. Protect from light. |
| Solubility overview | Soluble in DMSO (100 mM), and in ethanol (20 mM). Protect from light. |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol |
| Molecular Weight | 344.4 |
| Chemical structure | ![Methoxy-X04 [863918-78-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb5252_1.png "Methoxy-X04 [863918-78-9]") |
| Molecular Formula | C23H20O3 |
| CAS Number | 863918-78-9 |
| PubChem identifier | 16049314 |
| SMILES | COC1=C(C=CC(=C1)/C=C/C2=CC=C(C=C2)O)/C=C/C3=CC=C(C=C3)O |
| Source | Synthetic |
| InChi | InChI=1S/C23H20O3/c1-26-23-16-19(3-2-17-6-12-21(24)13-7-17)5-11-20(23)10-4-18-8-14-22(25)15-9-18/h2-16,24-25H,1H3/b3-2+,10-4+ |
| InChiKey | FGYNZFHVGOFCMD-KHVHPYDTSA-N |
| Appearance | Yellow solid |
References for Methoxy-X04
References are publications that support the biological activity of the product
-
A Study of Amyloid-beta and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients
Furcila D et al (2018) J Alzheimers Dis 64(2) : 417-435 -
Fibrillar amyloid plaque formation precedes microglial activation
Jung CK et al (2015) PLoS One 10(3) : e0119768 -
Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
Klunk WE et al (2002) J Neuropathol Exp Neurol 61(9) : 797-805
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