Product overview

Name L-Quisqualic acid
Description

AMPA receptor agonist and group I mGlu agonist

Alternative names QA, Quis, Quisqualate
Purity >99%
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Biological Data

Biological description

AMPA receptor agonist and group I mGlu agonist. Sensitizes hippocampal neurons to depolarization by excitatory amino acid analogues such as L-AP4, and L-AP6 ("the Quis effect"). Can also act as an excitotoxin and is used to lesion areas of the brain in rat models.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in NaOH(aq) (100mM, 1eq. NaOH) or water (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
Molecular Weight 189.13
Chemical structure L-Quisqualic acid  [52809-07-1] Chemical Structure
Molecular Formula C5H7N3O5
CAS Number 52809-07-01
PubChem identifier 40539
SMILES O=C1N(C[C@]([H])(N)C(O)=O)OC(N1)=O
InChi InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
InChiKey ASNFTDCKZKHJSW-REOHCLBHSA-N
MDL number MFCD00069337
Appearance White solid

References for L-Quisqualic acid

References are publications that support the biological activity of the product
  • Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury.

    Lee JW et al (2008) Neurosci Lett 439(2) : 212-5.
  • L-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization.

    Chase LA et al (2001) Neuroscience 106(2) : 287-301.
  • C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals.

    Giovannelli L et al (1998) J Neural Transm 105(8-9) : 935-48.
  • Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.

    Littman L et al (1995) Neuropharmacology 34(8) : 829-41.