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L-Quisqualic acid

(HB0387)
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Product overview

Name L-Quisqualic acid
Alternative names QA, Quis, Quisqualate
Purity >99%
Description

AMPA receptor agonist and group I mGlu agonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews References (4) Frequently bought together
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L-Quisqualic acid product vial image | Hello Bio
L-Quisqualic acid product vial image | Hello Bio

L-Quisqualic acid product vial image | Hello Bio

L-Quisqualic acid product vial image | Hello Bio

Biological Data

Biological description

AMPA receptor agonist and group I mGlu agonist. Sensitizes hippocampal neurons to depolarization by excitatory amino acid analogues such as L-AP4, and L-AP6 ("the Quis effect"). Can also act as an excitotoxin and is used to lesion areas of the brain in rat models.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in NaOH(aq) (100mM, 1eq. NaOH) or water (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
Molecular Weight 189.13
Chemical structure L-Quisqualic acid [52809-07-1] Chemical Structure
Molecular Formula C5H7N3O5
CAS Number 52809-07-01
PubChem identifier 40539
SMILES O=C1N(C[C@]([H])(N)C(O)=O)OC(N1)=O
InChi InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
InChiKey ASNFTDCKZKHJSW-REOHCLBHSA-N
MDL number MFCD00069337
Appearance White solid

References for L-Quisqualic acid

References are publications that support the biological activity of the product

  • Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury.

    Lee JW et al (2008) Neurosci Lett 439(2) : 212-5.
    Read more (PubMedID: 18524486)

  • L-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization.

    Chase LA et al (2001) Neuroscience 106(2) : 287-301.
    Read more (PubMedID: 11566501)

  • C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals.

    Giovannelli L et al (1998) J Neural Transm 105(8-9) : 935-48.
    Read more (PubMedID: 9869327)

  • Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.

    Littman L et al (1995) Neuropharmacology 34(8) : 829-41.
    Read more (PubMedID: 8532164)

4 Item(s)

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Grouped product items
Order: HB0387
Pack PriceQty
5mg
$87
10mg
$152
50mg
$604

AMPA receptor agonist and group I mGlu agonist

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Standard: $35

Hazardous: $35

Shipped on ice: $35

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