Product overview
Name | DNQX disodium salt |
Description | Selective, competitive AMPA / kainate receptor antagonist. Sodium salt. |
Purity | >98% |
Customer comments | DNQX disodium salt is a good product Verified customer, Research University Paris |
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Biological Data
Biological description | DNQX disodium salt is a water soluble, selective and competitive AMPA and kainate receptor antagonist. It also acts as partial AMPA agonist in the presence of γ2 transmembrane AMPA receptor regulatory proteins (TARP) subunit. DNQX is also a neuroleptic agent that displays pro-oxidant activity. DNQX freebase is also available. |
Application notes | DNQX disodium salt antagonizes the actions of glutamate at AMPA receptors. It is commonly used to reduce excitatory post synaptic currents (EPSC) and is commonly used at 10 μM. DNQX disodium salt from Hello Bio completely blocks both spontaneous and evoked EPSCs at 10 μM, with concentrations of 1 μM also effective (see Fig 1 above).
#Protocol 1: Evoked and spontaneous excitatory post synaptic currents (EPSCs)
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Solubility & Handling
Storage instructions | Room temperature (desiccate) |
Solubility overview | Soluble in water (100mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | 6,7-Dinitroquinoxaline-2,3-dione disodium salt |
Molecular Weight | 296.1 |
Chemical structure | |
Molecular Formula | C8H2N4Na2O6 |
CAS Number | 1312992-24-7 |
PubChem identifier | 45073428 |
SMILES | C1=C2C(=CC(=C1[N+](=O)[O-])[N+](=O)[O-])N=C(C(=N2)[O-])[O-].[Na+].[Na+] |
Source | Synthetic |
InChi | InChI=1S/C8H4N4O6.2Na/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7;;/h1-2H,(H,9,13)(H,10,14);;/q;2*+1/p-2 |
InChiKey | GPSBSOYURFUVKJ-UHFFFAOYSA-L |
Appearance | Brown solid |
References for DNQX disodium salt
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Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX).
Šarlauskas J et al (2013) Acta Biochim Pol 60(2) : 227-31. -
Selective excitatory actions of DNQX and CNQX in rat thalamic neurons.
Lee SH et al (2010) J Neurophysiol 103(4) : 1728-34. -
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists.
Menuz K et al (2007) Science 318(5851) : 815-7. -
Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.
Alt et al (2004) Neuropharmacology 46(6) : 793-806
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The selective dopamine D1 receptor agonist SKF81297 modulates NMDA receptor currents independently of D1 receptors
Nesbit MO et al (2022) Neuropharmacology 207 : 108967PubMedID: 35077763 -
Edinger-Westphal peptidergic neurons enable maternal preparatory nesting
Topilko T et al (2022) NeuronPubMedID: 35123655 -
Dysregulation of the Basal Ganglia Indirect Pathway in Early Symptomatic Q175 Huntington's Disease Mice
Callahan JW et al (2022) J Neurosci 42(10) : 2080-2102PubMedID: 35058372 -
Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175 +/- Mouse Model of Huntington's Disease
Lim and Surmeier (2021) Front Syst Neurosci . 14: : 626412PubMedID: 33551760 -
Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons
Goldberg et al (2021) bioRxiv https://doi.org/10.1101/2021.11.29.470423 : doi