DL-AP5 sodium salt

Technical documents: SDS CoA Datasheet

Product overview

Name DL-AP5 sodium salt
Alternative names DL-APV sodium salt
Purity >98%
Description Competitive NMDA receptor antagonist. Sodium salt.
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Figure 1. DL-AP5 sodium salt inhibition of evoked NMDAR mediated EPSCs in rat CA1 pyramidal neuron

DL-AP5 sodium salt is a water soluble NMDA receptor antagonist. It is typically used at a concentration of 50–100 µM. DL-AP5 sodium salt from Hello Bio reduces evoked NMDAR current with full receptor antagonism at 50 µM, consistent with the literature for this compound. For assay protocol, see #Protocol 1 in Application Notes below.
DL-AP5 sodium salt: Scientist Approved
DL-AP5 sodium salt product vial image | Hello Bio

Biological Data

Biological description

DL-AP5 sodium salt is a water soluble, competitive NMDA receptor antagonist and is the sodium salt of DL-AP5. DL-AP5 sodium salt binds at the glutamate site and impairs learning and fear conditioning.

Application notes

DL-AP5 sodium salt is a water soluble NMDA receptor antagonist. It is typically used at a concentration of 50–100 µM. DL-AP5 sodium salt from Hello Bio reduces evoked NMDAR current with full receptor antagonism at 50 µM (see Fig 1 above), consistent with the literature for this compound.


#Protocol 1: Evoked NMDAR currents at +40 mV

  • NMDAR currents were recorded via whole cell voltage clamp recordings of CA1 pyramidal neurons from rat hippocampal brain slice.
  • NMDAR currents were evoked via a stimulating electrode placed in the CA3 region to stimulate the Schaffer collateral pathway.
  • Each NMDAR current was evoked via a single square (150 µs) pulse every 10 sec at a stimulus intensity that gave a reliable NMDAR current.
  • Neurons were constantly held at +40 mV and NMDAR currents recorded in response to continual bath applications of NMDAR antagonists.
  • All NMDAR recordings were made in the presence of GABAA-R and AMPAR antagonists.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Handling Hydroscopic solid, contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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More Info

Chemical Data

Purity >98%
Chemical name DL-2-Amino-5-phosphonopentanoic acid sodium salt
Molecular Weight 219.11
Chemical structure DL-AP5 sodium salt  [1303993-72-7] Chemical Structure
Molecular Formula C5H11NNaO5P
CAS Number 1303993-72-7
PubChem identifier 52974251
SMILES C(CC(C(=O)O)N)CP(=O)(O)[O-].[Na+]
Source Synthetic
InChi InChI=1S/C5H12NO5P.Na/c6-4(5(7)8)2-1-3-12(9,10)11;/h4H,1-3,6H2,(H,7,8)(H2,9,10,11);/q;+1/p-1
Appearance White solid

References for DL-AP5 sodium salt

References are publications that support the biological activity of the product
  • Infusion of the NMDA receptor antagonist, DL-APV, into the basolateral amygdala disrupts learning to fear a novel and a familiar context as well as relearning to fear an extinguished context.

    Laurent V et al (2009) Learn Mem 16(1) : 96-105.
  • The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear.

    Laurent V et al (2008) Learn Mem 15(5) : 304-14.
  • Comparative analysis of different competitive antagonists interaction with NR2A and NR2B subunits of NMDA ionotropic glutamate receptor.

    Blaise MC et al (2005) J Mol Model 11(6) : 489-502.

3 Item(s)

These publications cite the use of DL-AP5 sodium salt purchased from Hello Bio:
  • The positive allosteric modulator of NMDA receptors, GNE-9278, blocks the ethanol-induced decrease of excitability in developing retrosplenial cortex neurons from mice.

    Bird CW et al (2023) Neuropsychopharmacology reports 43 : 77-84
    PubMedID: 36524248
  • Mild stress accumulation limits GABAergic synaptic plasticity in the lateral habenula

    Lalive AL et al (2022) Eur J Neurosci 55(2) : 377-387
    PubMedID: 34963191
  • Sex-specific effect of prenatal alcohol exposure on N-methyl-D-aspartate receptor function in orbitofrontal cortex pyramidal neurons of mice

    Licheri V et al (2021) Alcohol Clin Exp Res 45(10) : 1994-2005
    PubMedID: 34523139
  • NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models

    Ghatak S et al (2021) Mol Psychiatry 26(10) : 5751-5765
    PubMedID: 32467645
  • Neonatal ethanol exposure triggers apoptosis in the murine retrosplenial cortex: Role of inhibition of NMDA receptor-driven action potential firing

    Bird CW et al (2020) Neuropharmacology 162 : 107837
    PubMedID: 31689422

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