DL-AP5 sodium salt is a water soluble, competitive NMDA receptor antagonist and is the sodium salt of DL-AP5. DL-AP5 sodium salt binds at the glutamate site and impairs learning and fear conditioning.
DL-AP5 sodium salt is a water soluble NMDA receptor antagonist. It is typically used at a concentration of 50–100 µM. DL-AP5 sodium salt from Hello Bio reduces evoked NMDAR current with full receptor antagonism at 50 µM (see Fig 1 above), consistent with the literature for this compound.
#Protocol 1: Evoked NMDAR currents at +40 mV
NMDAR currents were recorded via whole cell voltage clamp recordings of CA1 pyramidal neurons from rat hippocampal brain slice.
NMDAR currents were evoked via a stimulating electrode placed in the CA3 region to stimulate the Schaffer collateral pathway.
Each NMDAR current was evoked via a single square (150 µs) pulse every 10 sec at a stimulus intensity that gave a reliable NMDAR current.
Neurons were constantly held at +40 mV and NMDAR currents recorded in response to continual bath applications of NMDAR antagonists.
All NMDAR recordings were made in the presence of GABAA-R and AMPAR antagonists.
Solubility & Handling
Room temperature (desiccate)
Soluble in water (100mM)
Hydroscopic solid, contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.