CP 465022 hydrochloride

(HB0214)
Technical documents: SDS Datasheet

Product overview

Description Potent, non-competitive AMPA receptor antagonist
Alternative names CP 392110
Purity >99%
Customer comments

Good price, fast delivery Verified customer, University of Copenhagen

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Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (10mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H) -quinazolinone hydrochloride
Molecular Weight 499.41
Chemical structure Product image
Molecular Formula C26H24ClFN4O.HCl
CAS Number 199655-36-2
PubChem identifier 67241566
SMILES CCN(CC)CC1=CC=CC(=N1)C=CC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4Cl.Cl
InChi InChI=1S/C26H24ClFN4O.ClH/c1-3-31(4-2)17-20-9-7-8-19(29-20)13-15-25-30-23-14-12-18(28)16-21(23)26(33)32(25)24-11-6-5-10-22(24)27;/h5-16H,3-4,17H2,1-2H3;1H
InChiKey YKYDGCRJPYLXHY-UHFFFAOYSA-N

References for CP 465022 hydrochloride

References are publications that support the biological of the product
  • Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists.

    Menniti FS et al (2000) Mol Pharmacol 58(6) : 1310-7.
  • CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.

    Menniti FS et al (2003) Stroke 34(1) : 171-6.
  • Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist.

    Lazzaro JT et al (2002) Neuropharmacology 42(2) : 143-53.
Publications
Publications are journal papers that use Hello Bio products. Selected Publications for CP 465022 hydrochloride include:
  • Mutational Analysis and Modeling of Negative Allosteric Modulator Binding Sites in AMPA Receptors

    Stenum-Berg et al (835-850) Mol Pharmacol. : 96(6)
    PubMedID: 31582576

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