Product overview
| Description | Potent, non-competitive AMPA receptor antagonist |
| Alternative names | CP 392110 |
| Purity | >99% |
| Customer comments | Good price, fast delivery Verified customer, University of Copenhagen |
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Solubility & Handling
| Storage instructions | Room temperature (desiccate) |
| Solubility overview | Soluble in water (10mM) and in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H) -quinazolinone hydrochloride |
| Molecular Weight | 499.41 |
| Chemical structure |  |
| Molecular Formula | C26H24ClFN4O.HCl |
| CAS Number | 199655-36-2 |
| PubChem identifier | 67241566 |
| SMILES | CCN(CC)CC1=CC=CC(=N1)C=CC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4Cl.Cl |
| InChi | InChI=1S/C26H24ClFN4O.ClH/c1-3-31(4-2)17-20-9-7-8-19(29-20)13-15-25-30-23-14-12-18(28)16-21(23)26(33)32(25)24-11-6-5-10-22(24)27;/h5-16H,3-4,17H2,1-2H3;1H |
| InChiKey | YKYDGCRJPYLXHY-UHFFFAOYSA-N |
References for CP 465022 hydrochloride
References are publications that support the biological of the product
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Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists.
Menniti FS et al (2000) Mol Pharmacol 58(6) : 1310-7. -
CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.
Menniti FS et al (2003) Stroke 34(1) : 171-6. -
Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist.
Lazzaro JT et al (2002) Neuropharmacology 42(2) : 143-53.
Publications
Publications are journal papers that use Hello Bio products. Selected Publications for CP 465022 hydrochloride include:
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Mutational Analysis and Modeling of Negative Allosteric Modulator Binding Sites in AMPA Receptors
Stenum-Berg et al (835-850) Mol Pharmacol. : 96(6)PubMedID: 31582576
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