CP 465022 hydrochloride

(HB0214)
Technical documents: SDS Datasheet

Product overview

Name CP 465022 hydrochloride
Description Potent, non-competitive AMPA receptor antagonist
Alternative names CP 392110
Purity >99%
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Biological Data

Biological description

Potent and non-competitive AMPA receptor antagonist (IC50 = 25 nM). Weakly inhibits NMDA, GABA and kainate receptors. Displays anticonvulsant actions.


This product is a mixture of the active isomer CP 465022 and the inactive isomer CP 465021. The mixture itself is also known as CP 392110.


Please note that there is confusion in the life science marketplace and scientific literature regarding the correct naming of this product and typically, where the product is cited as CP465022, it is generally the mixture of both isomers that is being referred to. If you need any further clarification, please contact customercare@hellobio.com

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (10mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H) -quinazolinone hydrochloride
Molecular Weight 499.41
Chemical structure CP 465022 hydrochloride  [199655-36-2] Chemical Structure
Molecular Formula C26H24ClFN4O.HCl
CAS Number 199655-36-2
PubChem identifier 67241566
SMILES CCN(CC)CC1=CC=CC(=N1)C=CC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4Cl.Cl
InChi InChI=1S/C26H24ClFN4O.ClH/c1-3-31(4-2)17-20-9-7-8-19(29-20)13-15-25-30-23-14-12-18(28)16-21(23)26(33)32(25)24-11-6-5-10-22(24)27;/h5-16H,3-4,17H2,1-2H3;1H
InChiKey YKYDGCRJPYLXHY-UHFFFAOYSA-N

References for CP 465022 hydrochloride

References are publications that support the biological activity of the product
  • CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.

    Menniti FS et al (2003) Stroke 34(1) : 171-6.
  • Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist.

    Lazzaro JT et al (2002) Neuropharmacology 42(2) : 143-53.
  • Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists.

    Menniti FS et al (2000) Mol Pharmacol 58(6) : 1310-7.
Publications
These publications cite the use of CP 465022 hydrochloride purchased from Hello Bio:
  • Mutational Analysis and Modeling of Negative Allosteric Modulator Binding Sites in AMPA Receptors

    Stenum-Berg et al (2019) Mol Pharmacol. 835-850 : 96(6)
    PubMedID: 31582576

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