Product overview
Name | CNQX |
Description | Potent, competitive AMPA / kainate receptor antagonist |
Purity | >98% |
Customer comments | Absolute satisfaction not only with item received, but especially with communication. This product (CNQX) meets our expectation and description as declared on websites. Communication was immediate and fast. Item came second day after purchase has been done, firmly packed. Unrivaled prices, friendly approach! Verified customer, National institute of mental health Czech Republic Another quality compound! CNQX from Hello Bio works great in our experiments and at a price that is definitely nice! We continue to be impressed with the value we get from this company. Verified customer, University of South Carolina |
Images
Biological Data
Biological description | Potent and competitive AMPA and kainate receptor antagonist. Also antagonises NMDA receptors at the glycine site. Increases GABAA receptor spontaneous postsynaptic currents (sPSCs). Shows neuroprotective actions. Water soluble, CNQX disodium salt also available. |
Application notes | The AMPA receptor antagonist CNQX is commonly used at concentrations of 10 μM to inhibit the actions of glutamate acting on AMPARs. CNQX from Hello Bio reduces both spontaneous and evoked EPSCs in cortical neurons at concentrations of 1 μM with full AMPA receptor blockade at 10 μM (see Fig 1 above).
#Protocol 1: Evoked and spontaneous excitatory post synaptic currents (EPSCs)
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Solubility & Handling
Storage instructions | Room temperature |
Solubility overview | Soluble in DMSO (100mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | 6-Cyano-7-nitroquinoxaline-2,3-dione |
Molecular Weight | 232.16 |
Chemical structure | |
Molecular Formula | C9H4N4O4 |
CAS Number | 115066-14-3 |
PubChem identifier | 3721046 |
SMILES | C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N |
Source | Synthetic |
InChi | InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15) |
InChiKey | RPXVIAFEQBNEAX-UHFFFAOYSA-N |
MDL number | MFCD00069232 |
Appearance | Yellow solid |
References for CNQX
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Dop neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons
Chuhma et al (2018) eLIFE 7:e39786 : DOI: 10.7554/eLife.39786 -
The calpain inhibitor MDL-28170 and the AMPA/KA receptor antagonist CNQX inhibit neurofilament degradation and enhance neuronal survival in kainic acid-treated hippocampal slice cultures.
Lopez-Picon FR et al (2006) Eur J Neurosci 23(10) : 2686-94. -
6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) increases GABAA receptor-mediated spontaneous postsynaptic currents in the dentate granule cells of rat hippocampal slices.
Hashimoto Y et al (2004) Neurosci Lett 358(1) : 33-6. -
Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.
Alt et al (2004) Neuropharmacology 46(6) : 793-806 -
6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor.
Birch PJ et al (1988) Eur J Pharmacol 156(1) : 177-80.
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Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory
Lepennetier et al (2018) Front. Cell. Neurosci. https://doi.org/ : 10.3389/fncel.2018.00318 -
Artifactual hyperpolarization during extracellular electrical stimulation: Proposed mechanism of high-rate neuromodulation
Lesperance et al (2017) Brain stimulation xxx : 1-10 -
SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development.
Choi et al (2016) Sci Rep 26 : 6:26676PubMedID: 27225731