Your Top Technical Questions Answered – CNO Storage & Stability
At Hello Bio, we’re proud to offer high-quality life science reagents, fair prices, and fast global delivery — backed by expert scientific support. When researchers ask us technical questions about optimal storage, solubility, or application, our PhD-qualified team is always ready to help.
In this month’s most-asked technical question, we’re spotlighting one of our most popular DREADD ligands — CNO dihydrochloride (HB6149). Cited in over 85 peer-reviewed papers, this water-soluble Clozapine N-oxide is a go-to chemogenetic tool trusted by labs worldwide.
★ Your Top Technical Question
“We noticed our CNO dihydrochloride wasn’t packaged in dry ice when it arrived and since arrival it has been stored at room temperature. Should we have frozen it, and will it still be usable?”
Absolutely — our small molecule compounds are shipped at room temperature because they remain stable under normal shipping conditions.
While we recommend storage at -20°C for optimal long-term preservation, short-term room temperature exposure (even for days or weeks) will not impact compound integrity or performance.
You can expect your product to behave exactly as intended.
What is CNO Dihydrochloride Used For?
CNO dihydrochloride is widely used in neuroscience and behavioral research as a selective chemogenetic actuator - it selectively modulates neuronal activity in DREADD (Designer Receptors Exclusively Activated by Designer Drugs) systems.
CNO enables researchers to reversibly activate or inhibit targeted neurons by binding to these designer receptors without affecting endogenous receptor systems. This makes it particularly valuable in studies of neural circuits, behavior, and neuropsychiatric disorders. The dihydrochloride form reduces concerns about variability with improved solubility and more reliable pharmacokinetics making it highly suitable for in vivo studies.
View CNO dihydrochloride (HB6149)
Which CNO Molecular Weight Should I Use For My Calculations – Product Label or COA?
A common point of confusion relates to molecular weight. If your CNO product label lists a slightly different MW than your technical documentation, don’t worry — differences can occur due to varying water content or salt forms. The most accurate value for calculations is always the batch-specific MW listed on your certificate of analysis (CoA), and you should always use this for any calculations.
More About CNO & DREADDS
- View CNO Dihydrochloride (HB6149)
- Browse our full range of DREADD ligands
- Stability of Water-Soluble DREADD Ligands: A Technical Review
More Help from Our Team
Have a technical question about CNO, DREADDs, or any other Hello Bio product? Our technical team is here to help.
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