BAPTA-AM

(HB0981)
Technical documents: SDS Datasheet

Product overview

Name BAPTA-AM
Description Cell permeable Ca2+ chelator
Purity >95%
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Biological Data

Biological description Cell permeable Ca2+ chelator. Hydrolysed by cytosolic esterases. Useful for manipulation of cellular Ca2+ levels. Open channel blocker of Kv channels (IC50 values are 1.3, 1.45 and 1.23 µM for Kv 11.1, hKv 1.3 and hKv 1.5 channels respectively). BAPTA analog.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (30mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 1,2-Bis(2-aminophenoxy)ethane-N,N,N ',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
Molecular Weight 764.68
Chemical structure BAPTA-AM  [126150-97-8] Chemical Structure
Molecular Formula C34H40N2O18
CAS Number 126150-97-8
PubChem identifier 2293
SMILES O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O
InChiKey YJIYWYAMZFVECX-UHFFFAOYSA-N

References for BAPTA-AM

References are publications that support the biological activity of the product
  • Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase.

    Chi Y et al (2011) J Pharmacol Exp Ther 339(1) : 257-66.
  • The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells.

    Tang Q et al (2007) Biochem Pharmacol 74(11) : 1596-607.
  • BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.

    Wie MB et al (2001) Prog Neuropsychopharmacol Biol Psychiatry 25(8) : 1641-59.
Publications
These publications cite the use of BAPTA-AM purchased from Hello Bio:
  • Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC.

    Modica et al. (2019) Cancers (Basel) 11(10) : E1588
    PubMedID: 31635301

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