YM-254890

G_q- G-protein inhibitor which potently inhibits Gq/11 heterotrimeric G protein signaling by blocking GDP exchange of GTP on the α- subunit of the G_q complex. Recently reported to act as a broad-spectrum inhibitor for Gq- and Gs-proteins and exhibits a biased inhibition on Gi/o signaling, without affecting non-GPCR-mediated cellular signaling (Peng et al 2021). Shown to attenuate ADP-, collagen-, TRAP-, arachidonic acid- and U46619-induced platelet aggregation to show antithrombotic effects.

-20°C

Soluble in DMSO (10mg/ml)

[(1R)-1-[(3S,6S,9S,12S,18R,21S,22R)-21-acetamido-18-benzyl-3-[(1R)-1-methoxyethyl]-4,9,10,12,16,22-hexamethyl-15-methylidene-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentazacyclodocos-6-yl]-2-methylpropyl] (2S,3R)-2-acetamido-3-hydroxy-4-methylpentanoate