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Biological Data

Biological description Na+ channel activator. Binds to active channels and prevents the inactive state. Increases persistent sodium current and intracellular Ca2+. Increases reverse Na+ / Ca2+ exchange current, pump activity and exocytosis. Induces action potentials and extended membrane depolarization.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β, 12,14,16β,17,20-hexaol
Molecular Weight 673.79
Chemical structure Veratridine  [71-62-5] Chemical Structure
Molecular Formula C36H51NO11
CAS Number 71-62-5
PubChem identifier 6280
SMILES O=C(C8=CC=C(OC)C(OC)=C8)O[C@H]1CC[C@@]2(C)[C@@]3([H])[C@@](O)1O[C@@]42[C@@]([C@@](C[C@H](O)[C@@]6(O)[C@]([H])5CN7[C@](CC[C@H](C)C7)([H])[C@@](O)6C)(O)[C@@]5(O)C4)([H])CC3

References for Veratridine

References are publications that support the biological activity of the product
  • [Involvement of veratridine-induced increase of reverse Na(+)/Ca(2+) exchange current in intracellular Ca(2+) overload and extension of action potential duration in rabbit ventricular myocytes].

    Kong LH et al (2012) Sheng Li Xue Bao 64(4) : 433-43.
  • Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy.

    Fekete A et al (2009) J Neurochem 111(3) : 745-56.
  • Effects of veratridine on sodium currents and fluxes.

    Ulbricht W (1998) Rev Physiol Biochem Pharmacol 133 : 1-54.
  • Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine.

    Maroto R et al (1994) Eur J Pharmacol 270(4) : 331-9.

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