My Cart
My account
Menu
Main Menu

ω-Conotoxin GVIA

(HB1218)
Publications (1)
Technical documents: SDS CoA Datasheet
Be the first to review this product
Add to Wish List

Product overview

Name ω-Conotoxin GVIA
Alternative names ω-CTX, ω-CgTx; SNX-124
Purity >98%
Special requirements

As this product is a toxin, customers are required to complete a short end user declaration when ordering. Our customer care team will be happy to help you with this.

This is a home office notifiable schedule 5 toxin.

Description Potent, selective Cav2.2 (N-type) channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (1) References (4) Frequently bought together
Write Your Own Review
You're reviewing:ω-Conotoxin GVIA
Rate this item:

Biological Data

Biological description

Conotoxin GVIA is a peptide neurotoxin which is a potent, selective and partially reversible Cav2.2 (N-type) calcium channel blocker (IC50 = 0.15 nM). ω-Conotoxin GVIA binds the Cav2.2 α1 subunit (α1B).


Conotoxin GVIA inhibits presynaptic Cav2.2 channels, reduces glutamate release and irreversibly blocks synaptic transmission.


It also attenuates (RS)-3,5-DHPG-induced LTD (long term depression).


It shows antinociceptive action and attenuates hyperalgesia and allodynia.


Conotoxin GVIA is active in vivo.

Solubility & Handling

Solubility overview Soluble in water (1mg/ml)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name H-Cys(1)-Lys-Ser-Hyp-Gly-Ser-Ser-Cys(2)-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys(3)-Cys(1)-Arg-Ser-Cys(2)-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys(3)-Tyr-NH2 trifluoroacetate salt
Molecular Weight 3037
Molecular Formula C120H182N38O43S6
CAS Number 106375-28-4
PubChem identifier 16133838
SMILES C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N5C[C@@H](C[C@H]5C(=O)N1)O)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CO)CCCNC(=N)N)NC2=O)N)CCCCN)CO)O)CO)CO)CC(=O)N)O)CC7=CC=C(C=C7)O)[C@@H](C)O)CCCCN)CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)N)CC(=O)N)CC9=CC=C(C=C9)O)CO)O
InChi InChI=1S/C120H182N38O43S6/c1-53(165)91-114(197)138-66(10-4-6-26-122)95(178)136-68(12-8-28-132-120(129)130)98(181)149-81(107(190)139-69(93(126)176)29-55-13-19-58(167)20-14-55)49-204-207-52-84-110(193)153-80-48-203-202-47-64(123)94(177)135-65(9-3-5-25-121)9
InChiKey FDQZTPPHJRQRQQ-NZPQQUJLSA-N
MDL number MFCD00076620

References for ω-Conotoxin GVIA

References are publications that support the biological activity of the product

  • Complex structures between the N-type calcium channel (CaV2.2) and ω-conotoxin GVIA predicted via molecular dynamics.

    Chen R et al (2013) Biochemistry 52(21) : 3765-72.
    Read more (PubMedID: 23651160)

  • Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression.

    Connelly et al (2011) Eur J Pharmacol 667(1-3) : 160-8
    Read more (PubMedID: 21575629)

  • omega-Conotoxin reduces facilitation of transmitter release at the frog neuromuscular junction.

    Zengel et al (1993) Brain Res 611(1) : 25-30
    Read more (PubMedID: 8100174)

  • The effect of omega-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro.

    Home and Kemp (1991) Br J Pharmacol 103(3) : 1733-9
    Read more (PubMedID: 1657265)

4 Item(s)

Publications
Submit Yours Now
These publications cite the use of ω-Conotoxin GVIA purchased from Hello Bio:

  • Calcium-induced calcium release activates spontaneous miniature outward currents in newt medullary reticular formation neurons

    Yaeger DB et al (2018) J Neurophysiol 120(6) : 3140-3154
    PubMedID: 29897864

1 Item

Related Products
Grouped product items
Order: HB1218
Pack PriceQty
100μg
$127
250μg
$308
500μg
$354
1mg
$573
Potent, selective Cav2.2 (N-type) channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

Related Products

Tetrodotoxin citrate
Code:
HB1035
Pack:
1mg
Price:
$267
Potent, selective, use-dependent Na+ channel blocker. Citrate Salt.
ω-Conotoxin MVIIC
Code:
HB1219
Pack:
100μg, 500μg
Price:
$204, $710
N-, P- and Q-type voltage-dependent Ca2+ channel blocker
ω-Agatoxin IVA
Code:
HB1212
Pack:
10μg, 100μg
Price:
$154, $431

Potent, selective P-type / Q-type Ca2+ channel blocker