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Biological Data Biological description Conotoxin GVIA is a peptide neurotoxin which is a potent, selective and partially reversible Cav 2.2 (N-type) calcium channel blocker (IC50 = 0.15 nM). ω-Conotoxin GVIA binds the Cav 2.2 α1 subunit (α1B).
v 2.2 channels, reduces glutamate release and irreversibly blocks synaptic transmission.
(RS)-3,5-DHPG -induced LTD (long term depression).
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name H-Cys(1)-Lys-Ser-Hyp-Gly-Ser-Ser-Cys(2)-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys(3)-Cys(1)-Arg-Ser-Cys(2)-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys(3)-Tyr-NH2 trifluoroacetate salt
Molecular Formula C120 H182 N38 O43 S6
PubChem identifier 16133838
SMILES C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N5C[C@@H](C[C@H]5C(=O)N1)O)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CO)CCCNC(=N)N)NC2=O)N)CCCCN)CO)O)CO)CO)CC(=O)N)O)CC7=CC=C(C=C7)O)[C@@H](C)O)CCCCN)CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)N)CC(=O)N)CC9=CC=C(C=C9)O)CO)O
InChi InChI=1S/C120H182N38O43S6/c1-53(165)91-114(197)138-66(10-4-6-26-122)95(178)136-68(12-8-28-132-120(129)130)98(181)149-81(107(190)139-69(93(126)176)29-55-13-19-58(167)20-14-55)49-204-207-52-84-110(193)153-80-48-203-202-47-64(123)94(177)135-65(9-3-5-25-121)9
InChiKey FDQZTPPHJRQRQQ-NZPQQUJLSA-N
References for ω-Conotoxin GVIA References are publications that support the biological activity of the product
Complex structures between the N-type calcium channel (CaV2.2) and ω-conotoxin GVIA predicted via molecular dynamics. Chen R et al (2013) Biochemistry 52(21) : 3765-72. Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression. Connelly et al (2011) Eur J Pharmacol 667(1-3) : 160-8 omega-Conotoxin reduces facilitation of transmitter release at the frog neuromuscular junction. Zengel et al (1993) Brain Res 611(1) : 25-30 The effect of omega-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro. Home and Kemp (1991) Br J Pharmacol 103(3) : 1733-9
Publications
These publications cite the use of ω-Conotoxin GVIA purchased from Hello Bio:
Calcium-induced calcium release activates spontaneous miniature outward currents in newt medullary reticular formation neurons Yaeger DB et al (2018) J Neurophysiol 120(6) : 3140-3154
Potent, selective Cav 2.2 (N-type) channel blocker
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