Product overview
| Name | ω-Conotoxin GVIA |
| Description | Potent, selective Cav2.2 (N-type) channel blocker |
| Alternative names | ω-CTX, ω-CgTx; SNX-124 |
| Purity | >98% |
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Biological Data
| Biological description | Conotoxin GVIA is a peptide neurotoxin which is a potent, selective and partially reversible Cav2.2 (N-type) calcium channel blocker (IC50 = 0.15 nM). ω-Conotoxin GVIA binds the Cav2.2 α1 subunit (α1B).
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Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in water (1mg/ml) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | H-Cys(1)-Lys-Ser-Hyp-Gly-Ser-Ser-Cys(2)-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys(3)-Cys(1)-Arg-Ser-Cys(2)-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys(3)-Tyr-NH2 trifluoroacetate salt |
| Molecular Weight | 3037 |
| Molecular Formula | C120H182N38O43S6 |
| CAS Number | 106375-28-4 |
| PubChem identifier | 16133838 |
| SMILES | C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N5C[C@@H](C[C@H]5C(=O)N1)O)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CO)CCCNC(=N)N)NC2=O)N)CCCCN)CO)O)CO)CO)CC(=O)N)O)CC7=CC=C(C=C7)O)[C@@H](C)O)CCCCN)CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)N)CC(=O)N)CC9=CC=C(C=C9)O)CO)O |
| InChi | InChI=1S/C120H182N38O43S6/c1-53(165)91-114(197)138-66(10-4-6-26-122)95(178)136-68(12-8-28-132-120(129)130)98(181)149-81(107(190)139-69(93(126)176)29-55-13-19-58(167)20-14-55)49-204-207-52-84-110(193)153-80-48-203-202-47-64(123)94(177)135-65(9-3-5-25-121)9 |
| InChiKey | FDQZTPPHJRQRQQ-NZPQQUJLSA-N |
| MDL number | MFCD00076620 |
References for ω-Conotoxin GVIA
References are publications that support the biological activity of the product
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Complex structures between the N-type calcium channel (CaV2.2) and ω-conotoxin GVIA predicted via molecular dynamics.
Chen R et al (2013) Biochemistry 52(21) : 3765-72. -
Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression.
Connelly et al (2011) Eur J Pharmacol 667(1-3) : 160-8 -
omega-Conotoxin reduces facilitation of transmitter release at the frog neuromuscular junction.
Zengel et al (1993) Brain Res 611(1) : 25-30 -
The effect of omega-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro.
Home and Kemp (1991) Br J Pharmacol 103(3) : 1733-9
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