My Cart
My account
Menu
Main Menu

QNZ 46

(HB0541)
Be the first to add a publication
Technical documents: SDS CoA Datasheet
Be the first to review this product
Add to Wish List

Product overview

Name QNZ 46
Purity >98%
Description GluN2C/D selective, non-competitive NMDA receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews References (2) Frequently bought together
Write Your Own Review
You're reviewing:QNZ 46
Rate this item:

Biological Data

Biological description GluN2C/D (NR2C/NR2D) selective, non-competitive NMDA receptor antagonist (IC50 values are 182, 193,7.1 and 3.9 µM for GluN2A, GluN2B, GluN2C and GluN2D respectively). Binds to glutamate site. Approx 50-fold more selective for GluN2C/D than GluN2A/B.

Solubility & Handling

Storage instructions room temperature
Solubility overview soluble in DMSO (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name 4-[6-Methoxy-2-[(1E)-2-(3-nitrophen yl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid
Molecular Weight 443.41
Chemical structure Chemical Structure
Molecular Formula C24H17N3O6
CAS Number 1237744-13-6
PubChem identifier 46861929
SMILES O=C2C1=CC(OC)=CC=C1N=C(/C=C/C4=CC([N+]([O-])=O)=CC=C4)N2C3=CC=C(C(O)=O)C=C3
InChiKey GNLVJIICVWDSNI-LFYBBSHMSA-N

References for QNZ 46

References are publications that support the biological activity of the product

  • Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors

    Hansen et al (2011) J Neurosci. 9;31 : (1):3650-61
    Read more (PubMedID: 21389220)

  • Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists

    Mosley et al (2010) J Med Chem. 53(15) : 5476-90
    Read more (PubMedID: 20684595)

2 Item(s)

Related Products
Grouped product items
Order: HB0541
Pack PriceQty
25mg
$472
GluN2C/D selective, non-competitive NMDA receptor antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

New Products in this Area

CGP 78608 hydrochloride
HB0187

Selective, competitive GluN1 NMDAR receptor antagonist. Enhances GluN1/3 activation.

Related Products

D-AP5
Code:
HB0225
Pack:
1mg, 10mg, 50mg, 100mg, 50mM (add 1ml water), 100mM (add 1ml water)
Price:
$45, $116, $495, $685, $161, $289
(Free trial)

Selective, competitive NMDA receptor antagonist. Inhibits NMDAR-synaptic plasticity.

NBQX disodium salt
Code:
HB0443
Pack:
1mg, 10mg, 50mg, 50mM (add 1ml water), 100mM (add 1ml water)
Price:
$93, $193, $816, $460, $801
(Free trial)
Potent, selective, competitive AMPA receptor antagonist. Disodium salt.
TCN 201
Code:
HB0604
Pack:
10mg, 50mg
Price:
$176, $734
Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist