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Biological Data

Biological description GluN2C/D (NR2C/NR2D) selective, non-competitive NMDA receptor antagonist (IC50 values are 182, 193,7.1 and 3.9 µM for GluN2A, GluN2B, GluN2C and GluN2D respectively). Binds to glutamate site. Approx 50-fold more selective for GluN2C/D than GluN2A/B.

Solubility & Handling

Storage instructions room temperature
Solubility overview soluble in DMSO (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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References for QNZ 46

References are publications that support the biological activity of the product
  • Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors

    Hansen et al (2011) J Neurosci. 9;31 : (1):3650-61
  • Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists

    Mosley et al (2010) J Med Chem. 53(15) : 5476-90