Product overview
| Name | QNZ 46 |
| Description | GluN2C/D selective, non-competitive NMDA receptor antagonist |
| Purity | >98% |
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Biological Data
| Biological description | GluN2C/D (NR2C/NR2D) selective, non-competitive NMDA receptor antagonist (IC50 values are 182, 193,7.1 and 3.9 µM for GluN2A, GluN2B, GluN2C and GluN2D respectively). Binds to glutamate site. Approx 50-fold more selective for GluN2C/D than GluN2A/B. |
Solubility & Handling
| Storage instructions | room temperature |
| Solubility overview | soluble in DMSO (10mM, gentle warming) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
References for QNZ 46
References are publications that support the biological activity of the product
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Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors
Hansen et al (2011) J Neurosci. 9;31 : (1):3650-61 -
Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists
Mosley et al (2010) J Med Chem. 53(15) : 5476-90
Technical guides
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