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QNZ 46

(HB0541)
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Product overview

Name QNZ 46
Purity >98%
Description GluN2C/D selective, non-competitive NMDA receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews References (2) Frequently bought together
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Biological Data

Biological description GluN2C/D (NR2C/NR2D) selective, non-competitive NMDA receptor antagonist (IC50 values are 182, 193,7.1 and 3.9 µM for GluN2A, GluN2B, GluN2C and GluN2D respectively). Binds to glutamate site. Approx 50-fold more selective for GluN2C/D than GluN2A/B.

Solubility & Handling

Storage instructions room temperature
Solubility overview soluble in DMSO (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-[6-Methoxy-2-[(1E)-2-(3-nitrophen yl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid
Molecular Weight 443.41
Chemical structure Chemical Structure
Molecular Formula C24H17N3O6
CAS Number 1237744-13-6
PubChem identifier 46861929
SMILES O=C2C1=CC(OC)=CC=C1N=C(/C=C/C4=CC([N+]([O-])=O)=CC=C4)N2C3=CC=C(C(O)=O)C=C3
InChiKey GNLVJIICVWDSNI-LFYBBSHMSA-N

References for QNZ 46

References are publications that support the biological activity of the product

  • Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors

    Hansen et al (2011) J Neurosci. 9;31 : (1):3650-61
    Read more (PubMedID: 21389220)

  • Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists

    Mosley et al (2010) J Med Chem. 53(15) : 5476-90
    Read more (PubMedID: 20684595)

2 Item(s)

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Order: HB0541
Pack PriceQty
25mg
$472
GluN2C/D selective, non-competitive NMDA receptor antagonist
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