Tunicamycin is an antibiotic which is commonly used to induce ER (endoplasmic reticulum) stress and activate the unfolded protein response (UPR) to induce cell death.
Tunicamycin inhibits the DPAGT1 enzyme to inhibit one of the first steps of glycoprotein biosynthesis in the ER which results in the accumulation of misfolded proteins to cause subsequent ER stress.
ER stress can often be induced by treating cells with tunicamycin at 2.5-5 µg/ml of tunicamycin for 5 hours.
Solubility & Handling
Solubility overview
Soluble in DMSO (50mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![Tunicamycin [11089-65-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0880.png "Tunicamycin [11089-65-9]")
Understanding purity and quality - a guide for life scientists
