Product overview

Name Spadin
Biological description Potent TREK-1/ K2P2.1 potassium channel blocker (IC50 = 71 nM). Brain penetrant. Increases 5-HT neuron firing rate in the Dorsal Raphe Nucleus and shows fast-acting antidepressant effects. Also controls astrocytic passive conductance.
Purity >95%

Potent TREK-1/ K2P2.1 channel blocker. Shows fast-acting antidepressant effects.

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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Molecular Weight 2012.34
Chemical structure  Chemical Structure
Molecular Formula C96H142N26O22
Sequence (one letter) YAPLPRWSGPIGVSWGLR
CAS Number 1270083-24-3
PubChem identifier 91826106
SMILES CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC5=CC=CC=C54)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CC(C)C)NC(=O)[C@@H]7CCCN7C(=O)[C@H](C)NC(=O)[C@H](CC8=CC=C(C=C8)O)N
Appearance White solid

References for Spadin

References are publications that support the biological activity of the product
  • Spadin Modulates Astrocytic Passive Conductance via Inhibition of TWIK-1/TREK-1 Heterodimeric Channels.

    Bae Y et al (2020) International journal of molecular sciences 21 :
  • The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function.

    Moha ou Maati H et al (2016) Brain structure & function 221 : 21-37
  • Spadin as a new antidepressant: absence of TREK-1-related side effects.

    Moha Ou Maati H et al (2012) Neuropharmacology 62 : 278-88
  • Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.

    Mazella J et al (2010) PLoS biology 8 : e1000355

4 Item(s)