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Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical structure
Molecular Formula C96 H142 N26 O22
Sequence (one letter) YAPLPRWSGPIGVSWGLR
PubChem identifier 91826106
SMILES CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC5=CC=CC=C54)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CC(C)C)NC(=O)[C@@H]7CCCN7C(=O)[C@H](C)NC(=O)[C@H](CC8=CC=C(C=C8)O)N
InChiKey WMSPWLIEKXALQP-WSSJNERPSA-N
References for Spadin References are publications that support the biological activity of the product
Spadin Modulates Astrocytic Passive Conductance via Inhibition of TWIK-1/TREK-1 Heterodimeric Channels. Bae Y et al (2020) International journal of molecular sciences 21 : The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function. Moha ou Maati H et al (2016) Brain structure & function 221 : 21-37 Spadin as a new antidepressant: absence of TREK-1-related side effects. Moha Ou Maati H et al (2012) Neuropharmacology 62 : 278-88 Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. Mazella J et al (2010) PLoS biology 8 : e1000355
Potent TREK-1/ K2P2.1 channel blocker. Shows fast-acting antidepressant effects.
Understanding purity and quality - a guide for life scientists
