SB 216763

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Product overview

Name SB 216763
Alternative names SB-216763
Purity >98%
Description Potent, selective cell permeable GSK-3 inhibitor. Maintains mESCs and promotes retinal stem cells proliferation.
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Biological Data

Biological description

Potent, selective, cell permeable and ATP competitive GSK-3 inhibitor which is equally effective at GSK-3α as GSK-3β (IC50 = 34 nM for GSK-3α). Displays little activity at 24 other serine/threonine and tyrosine protein kinases.

SB 216763 is active in vivo.

The compound stimulates glycogen synthesis (EC50 = 3.6 µM), acts as a neuroprotectant and prevents neuronal cell death. It also shows anti-inflammatory and cardioprotective actions. 

It is also widely used in stem cell research, for example:


  • Maintains mESCs (mouse embryonic stem cells) in a pluripotent state in the absence of LIF when cultured with MEFs
  • Restores INS-dependent differentiation of C2ind myoblasts


  • Promotes the conversion of human umbilical cord mesenchymal stem cells into neural precursors
  • Enhances chondrogenic differentiation of hWJ-MSCs
  • Increases neurogenesis of human neural progenitor cell differentiation
  • Promotes neural differentiation of CD117-positive hAFS cells towards neural progenitor cells


  • Promotes the proliferation of retinal stem cells

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (75mM)
Handling This compound is light sensitive; we therefore recommend protecting the solid material and solutions from exposure to light.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Molecular Weight 371.22
Molecular Formula C19H12Cl2N2O2
CAS Number 280744-09-4
PubChem identifier 176158
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl
Source Synthetic
InChi InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
MDL number MFCD09753369
Appearance Orange solid

References for SB 216763

References are publications that support the biological activity of the product
  • Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion.

    Gross et al (2008) Am J Physiol Heart Circ Physiol 294(3) : 1495-500
  • Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary margin.

    Inoue et al (2006) Stem Cells 24(1) : 95-104
  • INS- and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy.

    Rochat et al (2004) Mol Biol Cell 15(10) : 4544-55
  • Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.

    Cross DA et al (2001) J Neurochem 77(1) : 94-102.
  • Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.

    Coghlan MP et al (2000) Chem Biol 7(10) : 793-803.

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