Class I and II histone deacetylase (HDAC) inhibitor (IC50 values are 10 and 20 nM for HDAC1 and HDAC3 respectively).
Induces accumulation of acetylated histones (H2A, H2B, H3 and H4 in transformed cultured cells).
Has a variety of actions - supresses cell growth in various cance cell lines, induces apoptoisis and activates autophagy. Also reduces pro-inflammatory cytokine production. Additionally shows anti-inflammatory, anti-retroviral, growth inhibitory and anti-cancer actions.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
The histone deacetylase inhibitor vorinostat (SAHA) increases the susceptibility of uninfected CD4+ T cells to HIV by increasing the kinetics and efficiency of postentry viral events.
![SAHA [149647-78-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1396.png "SAHA [149647-78-9]")
Understanding purity and quality - a guide for life scientists
