Class I and II histone deacetylase (HDAC) inhibitor (IC50 values are 10 and 20 nM for HDAC1 and HDAC3 respectively).
Induces accumulation of acetylated histones (H2A, H2B, H3 and H4 in transformed cultured cells).
Has a variety of actions - supresses cell growth in various cance cell lines, induces apoptoisis and activates autophagy. Also reduces pro-inflammatory cytokine production. Additionally shows anti-inflammatory, anti-retroviral, growth inhibitory and anti-cancer actions.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
The histone deacetylase inhibitor vorinostat (SAHA) increases the susceptibility of uninfected CD4+ T cells to HIV by increasing the kinetics and efficiency of postentry viral events.
![SAHA [149647-78-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1396.png "SAHA [149647-78-9]")
Understanding purity and quality - a guide for life scientists
