Excellent 5HT antagonist in vivo. Great price, very soluble, potency as expected in vivo. I will continue to buy this. Active in mice from 0.01mg/kg in saline via i.p. Verified customer, The University of Sydney
Description
Potent and selective 5-HT2A receptor antagonist. Water soluble.
More convenient and easier to use water soluble version of MDL 100907, which is only soluble in DMSO and HCl. MDL 100907 is a potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM). Shows > 80-fold selectivity for 5-HT2A over other 5-HT receptor subtypes. Displays antipsychotic actions. Active in vivo.
Solubility & Handling
Solubility overview
soluble in water (100mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
References for MDL100907 hydrochloride (Water soluble)
References are publications that support the biological activity of the product
Acute and repeated administration of the selective 5-HT(2A) receptor antagonist M100907 significantly alters the activity of midbrain dopamine neurons: an in vivo electrophysiological study.
Minabe Y et al (2001) Synapse (New York, N.Y.) 40 : 102-12
Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.
Kehne JH et al (1996) The Journal of pharmacology and experimental therapeutics 277 : 968-81
Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.
Sorensen SM et al (1993) The Journal of pharmacology and experimental therapeutics 266 : 684-91
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