Recombinant human CDNF protein

Technical documents: Datasheet

Product overview

Name Recombinant human CDNF protein
Biological description

Neurotrophin factor that is expressed in brain, neuronal and some non-neuronal tissues.

CDNF is mainly localized to the endoplasmic reticulum lumen and modulates the unfolded protein response (UPR) pathway.

It has been shown to promote survival, growth and function of dopamine-specific neurons.

It additionally shows neurorestorative effects in a number of Parkinson’s disease animal models.

Alternative names Recombinant Human Cerebral Dopamine Neurotrophic Factor, Cerebral neurotrophic factor, arginine-rich, mutated in early stage tumors-like 1, Conserved neurotrophic factor, ARMET-like protein 1, ARMETL1.
Purity >96%
Description Neurotrophin implicated in Parkinson’s disease research
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Biological Data

Application notes ED50 = 15-25µg/ml (determined by its ability to stimulate of proliferation of rat C6 cells) corresponding to a specific activity of 40-67units/mg.

Solubility & Handling

Solubility overview To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 100μg/ml, which can then be diluted to make a working solution
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >96%
Source E. Coli.
Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a 0.2μm filtered solution in PBS (pH 7.4)

References for Recombinant human CDNF protein

References are publications that support the biological activity of the product
  • CDNF Protein Therapy in Parkinson's Disease

    Huttunen HJ et al (2019) Cell Transplant 28(4) : 349-366
  • Characterization of recombinant human brain-derived neurotrophic factor variants

    Sunasara KM et al (1999) Arch Biochem Biophys 372(2) : 248-60
  • Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery

    Pardridge WM et al (1994) Pharm Res 11(5) : 738-46

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