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Raseglurant (ADX 10059 hydrochloride)

(HB1557)
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Technical documents: SDS CoA Datasheet

Product overview

Name Raseglurant (ADX 10059 hydrochloride)
Purity >98%
Description mGlu5 negative allosteric modulator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (3) Reviews References (2) Frequently bought together
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Biological Data

Biological description

mGlu5 receptor negative allosteric modulator. Analog of MPEP. Potential anti-reflux and anti-migraine actions. JF-NP-26 (Caged-Raseglurant) also available.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride
Molecular Weight 276.74
Chemical structure Raseglurant [757949-98-7] Chemical Structure
Molecular Formula C15H13N2F · HCl
CAS Number 757949-98-7
PubChem identifier 18454771
SMILES CC1=CC(=NC(=C1N)C#CC2=CC(=CC=C2)F)C.Cl
Source Synthetic
InChi InChI=1S/C15H13FN2.ClH/c1-10-8-11(2)18-14(15(10)17)7-6-12-4-3-5-13(16)9-12;/h3-5,8-9H,17H2,1-2H3;1H
InChiKey BDXXMGYKLQZXOU-UHFFFAOYSA-N
Appearance Yellow solid

References for Raseglurant (ADX 10059 hydrochloride)

References are publications that support the biological activity of the product

  • 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.

    Weiss JM et al (2011) Bioorg Med Chem Lett 21(16) : 4891-9.
    Read more (PubMedID: 21757343)

  • A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease.

    Keywood C et al (2009) Gut 58(9) : 1192-9.
    Read more (PubMedID: 19460767)

2 Item(s)

Related Products
Grouped product items
Order: HB1557
Pack PriceQty
10mg
$147
50mg
$602
mGlu5 negative allosteric modulator
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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Related Products

JF-NP-26 (Caged-Raseglurant)
Code:
HB6127
Pack:
1mg, 5mg
Price:
$66, $312
Novel, inactive photocaged derivative of raseglurant which can be uncaged with violet light. Shows light-dependent analgesic activity in vivo.
MPEP hydrochloride
Code:
HB0426
Pack:
10mg, 50mg
Price:
$118, $439
Potent, selective mGluR5 antagonist / mGluR4 positive allosteric modulator
MTEP hydrochloride
Code:
HB0431
Pack:
10mg, 50mg, 10mM (add 1ml water)
Price:
$128, $483, $50
Potent, highly selective, non-competitive mGluR5 antagonist