Quinolinic acid

(HB0544)
Technical documents: SDS Datasheet

Product overview

Name Quinolinic acid
Description Endogenous NMDA receptor agonist
Biological description Endogenous NMDA receptor agonist. Shows no activation at GluN1 and GluN2C subunit containing receptors. Displays neurotoxin and pro-inflammatory properties.
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Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in NaOH(aq) (50mM, 1eq. NaOH)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name Pyridine-2,3-dicarboxylic acid
Molecular Weight 167.12
Chemical structure Product image
Molecular Formula C7H5NO4
CAS Number 89-00-9
PubChem identifier 1066
SMILES OC(=O)C1=C(N=CC=C1)C(O)=O
InChiKey GJAWHXHKYYXBSV-UHFFFAOYSA-N

References for Quinolinic acid

References are publications that support the biological activity of the product
  • Quinolinic acid, the inescapable neurotoxin.

    Guillemin GJ (2012) FEBS J 279(8) : 1356-65.
  • The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.

    de Carvalho LP et al (1996) Neurochem Int 28(4) : 445-52.
  • Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.

    Heyes MP et al (1992) Brain 115 ( Pt 5) : 1249-73.
  • Quinolinic acid: an endogenous neurotoxin with multiple targets.

    Lugo-Huitrón R et al (2013) Oxid Med Cell Longev 2013 : 104024