Product overview
| Name | Quinolinic acid |
| Description | Endogenous NMDA receptor agonist |
| Purity | >98% |
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Biological Data
| Biological description | Endogenous NMDA receptor agonist. Shows no activation at GluN1 and GluN2C subunit containing receptors. Displays neurotoxin and pro-inflammatory properties. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in NaOH(aq) (50mM, 1eq. NaOH) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | Pyridine-2,3-dicarboxylic acid |
| Molecular Weight | 167.12 |
| Chemical structure | ![Quinolinic acid [89-00-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0544.png "Quinolinic acid [89-00-9]") |
| Molecular Formula | C7H5NO4 |
| CAS Number | 89-00-9 |
| PubChem identifier | 1066 |
| SMILES | OC(=O)C1=C(N=CC=C1)C(O)=O |
| InChiKey | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
References for Quinolinic acid
References are publications that support the biological activity of the product
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Quinolinic acid: an endogenous neurotoxin with multiple targets.
Lugo-Huitrón R et al (2013) Oxid Med Cell Longev 2013 : 104024 -
Quinolinic acid, the inescapable neurotoxin.
Guillemin GJ (2012) FEBS J 279(8) : 1356-65. -
The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.
de Carvalho LP et al (1996) Neurochem Int 28(4) : 445-52. -
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Heyes MP et al (1992) Brain 115 ( Pt 5) : 1249-73.
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