Concanavalin A (ConA)

Technical documents: SDS Datasheet

Product overview

Name Concanavalin A (ConA)
Alternative names ConA, Con A
Description T-cell stimulating lectin
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Biological Data

Biological description


Concanavalin A (also commonly known as ConA) is a mannose/glucose-binding lectin which irreversibly binds to glycoproteins on cell membranes causing the glycoprotein to internalize preferentially to the mitochondria to induce programmed cell death via autophagy.


Con A has a wide range of applications. It is a T-cell mitogen which is frequently used to stimulate / activate T-cells and activate the immune response.

ConA is often used to characterize glycoproteins and other glycan presenting cells and in addition, also agglutinates erythrocytes and a variety of cell types.

ConA shows various biological actions and can induce programmed cell death via mitochondria mediated apoptosis and autophagy.

ConA and PMA are often used in combination to stimulate DNA and protein synthesis at a greater extent than when applied individually.

Active in vivo.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (10 mg/ml)



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Chemical Data

CAS Number 11028-71-0
Source Canavalia ensiformis
MDL number MFCD00071069

References for Concanavalin A (ConA)

References are publications that support the biological activity of the product
  • Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics.

    Li et al (2011) Biochem Biophys Res Commun. 414(2) : 282-6
  • Induction of autophagy by concanavalin A and its application in anti-tumor therapy.

    Lei and Chang (2007) Autophagy 3(4) : 402-4
  • Effect of phorbol myristate acetate and concanavalin A on the glycolytic enzymes of human peripheral lymphocytes.

    Marjanovic et al (1988) Biochim Biophys Acta. 970(1) : 1-6
  • ConA- and PNA-binding glycoproteins of human epidermis.

    Reano et al (1984) J Invest Dematol 83(3) : 202-5
  • The use of concanavalin A to study the immunoregulation of human T cells.

    Dwyer and Johnson (1981) Clin Exp Immunol 46(2) : 237-49

5 Item(s)

These publications cite the use of Concanavalin A (ConA) purchased from Hello Bio:
  • PTC-174, a positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits

    Yi F et al (2020) Neuropharmacology 25 : 107971
    PubMedID: 31987864

1 Item