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G418 disulfate salt

Technical documents: SDS CoA Datasheet

Product overview

Name G418 disulfate salt
Description Antibiotic. Widely used in cell culture. Protein synthesis inhibitor.
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Biological Data

Biological description

Antibiotic. Inhibits protein synthesis to show cytotoxic activity.

Widely used in cell culture as a selection antibiotic for the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3' or APH II.

Also shows antiviral activity and induces apoptosis.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name O-2-Amino-2,7-dideoxy-D-glycero-α-D-glucoheptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-D-streptamine sulfate
Molecular Weight 692.71
Chemical structure G418 disulfate salt [108321-42-2] Chemical Structure
Molecular Formula C20H40N4O10.2H2SO4
CAS Number 108321-42-2
PubChem identifier 16218858
SMILES CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@H]3[C@H]([C@@H]([C@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
InChi InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
MDL number MFCD00058314
Appearance White solid

References for G418 disulfate salt

References are publications that support the biological activity of the product
  • A novel kanamycin/G418 resistance marker for direct selection of transformants in Escherichia coli and different yeast species.

    Agaphonov et al (2010) Yeast 27(4) : 189-95
  • The effects of G418 on the growth and metabolism of recombinant mammalian cell lines.

    Yallop and Svendsen (2001) Cytotechnology 35(2) : 101-14
  • Use of plasmid-mediated resistance to the antibiotic G418 for the rapid screening of a yeast mutant library.

    Chenevert et al (1984) J Exp Pathol 1(4) : 307-13

3 Item(s)

These publications cite the use of G418 disulfate salt purchased from Hello Bio:
  • Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms

    Bibic L et al (2019) J Nat Prod 82(9) : 2559-2567
    PubMedID: 31532206

1 Item