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Biological Data Biological description Selective K2P 2.1 (TREK-1) and K2P 10.1 (TREK-2) activator but inactive against K2P 4.1 (TRAAK) (EC50 values are 13.7 and 5.9 µM
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM), and in ethanol (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide
Chemical structure
Molecular Formula C14 H14 ClNO2 S
PubChem identifier 592973
SMILES CC1=C(C=CC(=C1)Cl)OCCNC(=O)C2=CC=CS2
InChi InChI=1S/C14H14ClNO2S/c1-10-9-11(15)4-5-12(10)18-7-6-16-14(17)13-3-2-8-19-13/h2-5,8-9H,6-7H2,1H3,(H,16,17)
InChiKey RULQUKFOBAPKKR-UHFFFAOYSA-N
References for ML 402 References are publications that support the biological activity of the product
K(2P)2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Lolicato M et al (2017) Nature 547 : 364-368
Selective K2P 2.1 (TREK-1) and K2P 10.1 (TREK-2) activator
Understanding purity and quality - a guide for life scientists
