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Biological Data
| Biological description | Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator but inactive against K2P4.1 (TRAAK) (EC50 values are 13.7 and 5.9 µM |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100 mM), and in ethanol (50 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide |
| Chemical structure |  |
| Molecular Formula | C14H14ClNO2S |
| PubChem identifier | 592973 |
| SMILES | CC1=C(C=CC(=C1)Cl)OCCNC(=O)C2=CC=CS2 |
| InChi | InChI=1S/C14H14ClNO2S/c1-10-9-11(15)4-5-12(10)18-7-6-16-14(17)13-3-2-8-19-13/h2-5,8-9H,6-7H2,1H3,(H,16,17) |
| InChiKey | RULQUKFOBAPKKR-UHFFFAOYSA-N |
References for ML 402
References are publications that support the biological activity of the product
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K(2P)2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Lolicato M et al (2017) Nature 547 : 364-368
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
Understanding purity and quality - a guide for life scientists
