My Cart
My account
Menu
Main Menu

ML 402

(HB6899)
Be the first to add a publication
Technical documents: Datasheet
Be the first to review this product
Add to Wish List

Product overview

Name ML 402
Alternative names ML-402, ML402
Purity >98%
Description

Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (1)
Write Your Own Review
You're reviewing:ML 402
Rate this item:

Biological Data

Biological description

Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator but inactive against K2P4.1 (TRAAK) (EC50 values are 13.7 and 5.9 µM

Solubility & Handling

Solubility overview Soluble in DMSO (100 mM), and in ethanol (50 mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide
Molecular Weight 295.78
Chemical structure 298684-44-3 Chemical Structure
Molecular Formula C14H14ClNO2S
CAS Number 298684-44-3
PubChem identifier 592973
SMILES CC1=C(C=CC(=C1)Cl)OCCNC(=O)C2=CC=CS2
InChi InChI=1S/C14H14ClNO2S/c1-10-9-11(15)4-5-12(10)18-7-6-16-14(17)13-3-2-8-19-13/h2-5,8-9H,6-7H2,1H3,(H,16,17)
InChiKey RULQUKFOBAPKKR-UHFFFAOYSA-N

References for ML 402

References are publications that support the biological activity of the product

  • K(2P)2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.

    Lolicato M et al (2017) Nature 547 : 364-368
    Read more (PubMedID: 28693035)

1 Item

Related Products
Grouped product items
Order: HB6899
Pack PriceQty
10mg
$85
50mg
$352

Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

Related Products

Spadin
Code:
HB5438
Pack:
1mg
Price:
$129

Potent TREK-1/ K2P2.1 channel blocker. Shows fast-acting antidepressant effects.

CAT335
Code:
HB8146
Pack:
5mg, 10mg, 25mg, 50mg, 100mg
Price:
$75, $111, $269, $460, $872

K2P2.1 (TREK-1) modulator. Used with ML336 as part of the CATKLAMP chemogenetic strategy. Selectively and irreversibly activates TREK-1CG* but not wild-type K2P2.1 (TREK-1)

 

ML 335
Code:
HB6763
Pack:
10mg, 50mg
Price:
$85, $352
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator