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Biological Data
| Biological description | Selective mGlu3 receptor negative allosteric modulator (IC50 = 0.66 µM). Displays 15-fold selectivity over mGlu2 receptor and is inactive against mGlu5 receptor. Blood-brain barrier permeable. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | [(3R)-3-(Hydroxymethyl)-1-pipridinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanone |
| Chemical structure | ![ML 289 [1382481-79-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "ML 289 [1382481-79-9]") |
| Molecular Formula | C22H23NO3 |
| PubChem identifier | 56587994 |
| SMILES | O=C(N3CCC[C@@H](CO)C3)C(C=C2)=CC=C2C#CC1=CC=C(OC)C=C1 |
| InChiKey | VSLWUPHHCFQTDB-LJQANCHMSA-N |
References for ML 289
References are publications that support the biological activity of the product
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Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.
Sheffler DJ et al (2012) Bioorg Med Chem Lett 22(12) : 3921-5.
Selective mGlu3 negative allosteric modulator
![ML 289 [1382481-79-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0414.png "ML 289 [1382481-79-9]")
Understanding purity and quality - a guide for life scientists
