Product overview

Name ML 289
Description Selective mGlu3 negative allosteric modulator
Purity >98%
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Biological Data

Biological description Selective mGlu3 receptor negative allosteric modulator (IC50 = 0.66 µM). Displays 15-fold selectivity over mGlu2 receptor and is inactive against mGlu5 receptor. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name [(3R)-3-(Hydroxymethyl)-1-pipridinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanone
Molecular Weight 349.42
Chemical structure ML 289  [1382481-79-9] Chemical Structure
Molecular Formula C22H23NO3
CAS Number 1382481-79-9
PubChem identifier 56587994
SMILES O=C(N3CCC[C@@H](CO)C3)C(C=C2)=CC=C2C#CC1=CC=C(OC)C=C1
InChiKey VSLWUPHHCFQTDB-LJQANCHMSA-N

References for ML 289

References are publications that support the biological activity of the product
  • Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.

    Sheffler DJ et al (2012) Bioorg Med Chem Lett 22(12) : 3921-5.