Product overview

Name LY 341495
Purity >98%
Description Potent, selective group II mGlu receptor antagonist
Write Your Own Review
You're reviewing:LY 341495
Rate this item:


LY 341495 product vial image | Hello Bio

Biological Data

Biological description Potent and selective group II mGlu receptor antagonist (IC50 values are 21 and 14nM for mGlu2 and mGlu3 receptors respectively). Exhibits 10-fold selectivity for mGlu2 receptor. Less effective on other mGlu receptors (IC50 values are 22, 8.2, 0.99 and 0.17µM for mGlu1a, 4, 5a, 7 and 8 receptors respectively. Also a relatively potent group III antagonist. Shows low effectiveness on NMDA receptors. Blood-brain barrier permeable. Displays anti-depressant effects.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



More Info


More Info

Chemical Data

Purity >98%
Chemical name (2S)-2-Amino-2-[(1S,2S)-2-carboxycy cloprop-1-yl]-3-(xanth-9-yl) propanoic acid
Molecular Weight 353.37
Chemical structure LY 341495  [201943-63-7] Chemical Structure
Molecular Formula C20H19NO5
CAS Number 201943-63-7
PubChem identifier 9819927
SMILES C1[C@@H]([C@H]1[C@@](CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O
InChi InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
MDL number MFCD00949707

References for LY 341495

References are publications that support the biological activity of the product
  • Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.

    Wright RA et al (2000) Naunyn Schmiedebergs Arch Pharmacol 362(6) : 546-54.
  • The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.

    Fitzjohn SM et al (1998) Neuropharmacology 37(12) : 1445-58.
  • LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.

    Kingston AE et al (1998) Neuropharmacology 37(1) : 1-12.

3 Item(s)