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Remdesivir

(HB9521)
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Product overview

Name Remdesivir
Alternative names GS-5734
Purity >98%
Description Adenosine triphosphate analog with broad-spectrum antiviral activity
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description

Adenosine triphosphate analog with broad-spectrum antiviral activity which metabolizes into its active form GS-441524.

Inhibits MERS-CoV or SARS-CoV-infected HAE cultures (EC50=74nM and 69nM) and murine hepatitis virus (MHV) (EC50=30nM).

Solubility & Handling

Solubility overview Soluble in DMSO (100 mM), and in ethanol (20 mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate
Molecular Weight 602.58
Chemical structure Remdesivir [1809249-37-3] Chemical Structure
Molecular Formula C27H35N6O8P
CAS Number 1809249-37-3
PubChem identifier 121304016
SMILES CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
InChi InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1
InChiKey RWWYLEGWBNMMLJ-YSOARWBDSA-N
MDL number MFCD31657351
Appearance White solid

References for Remdesivir

References are publications that support the biological activity of the product

  • The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

    Gordon CJ et al (2020) J Biol Chem 295(15) : 4773-4779
    Read more (PubMedID: 32094225)

  • Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

    Wang M et al (2020) Cell Res 30(3) : 269-271
    Read more (PubMedID: 32020029)

  • Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

    Warren TK et al (2016) Nature 531(7594) : 381-5
    Read more (PubMedID: 26934220)

3 Item(s)

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Grouped product items
Order: HB9521
Pack PriceQty
1mg
$47
10mg
$107
50mg
$433
Adenosine triphosphate analog with broad-spectrum antiviral activity
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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