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Biological Data
| Biological description | Adenosine triphosphate analog with broad-spectrum antiviral activity which metabolizes into its active form GS-441524.
Inhibits MERS-CoV or SARS-CoV-infected HAE cultures (EC50=74nM and 69nM) and murine hepatitis virus (MHV) (EC50=30nM). |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (100 mM), and in ethanol (20 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate |
| Chemical structure | ![Remdesivir [1809249-37-3] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Remdesivir [1809249-37-3]") |
| Molecular Formula | C27H35N6O8P |
| PubChem identifier | 121304016 |
| SMILES | CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4 |
| InChi | InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1 |
| InChiKey | RWWYLEGWBNMMLJ-YSOARWBDSA-N |
References for Remdesivir
References are publications that support the biological activity of the product
-
The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
Gordon CJ et al (2020) J Biol Chem 295(15) : 4773-4779 -
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
Wang M et al (2020) Cell Res 30(3) : 269-271 -
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Warren TK et al (2016) Nature 531(7594) : 381-5
Adenosine triphosphate analog with broad-spectrum antiviral activity
![Remdesivir [1809249-37-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb9521_1.png "Remdesivir [1809249-37-3]")
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