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Emetine dihydrochloride

(HB7389)
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Product overview

Name Emetine dihydrochloride
Purity >98%
Description Protein synthesis inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description

Protein synthesis inhibitor with anti-protozoal effects. It binds to the ribosomal E site of Plasmodium falciparum to inhibit malaria.

Also shows antiviral effects against various RNA and DNA viruses including Zika and HIV-1). Also identified to inhibit hCoV-OC43, hCoV-NL43, SARS-CoV,MERS-CoV, and MHV-A59 in vitro with EC50 values reported at low micro-molar range and can effectively inhibit SARS-CoV-2 virus replication.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions Store at +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4- tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10- dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido [2,1-a]isoquinoline dihydrochloride hydrate
Molecular Weight 480.64
Chemical structure Emetine [7083-71-8] Chemical Structure
Molecular Formula C29H40N2O4.2HCl
CAS Number 7083-71-8
PubChem identifier 201899
SMILES CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.O.Cl.Cl
InChi InChI=1S/C29H40N2O4.2ClH.H2O/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H;1H2/t18-,21-,24+,25-;;;/m0.../s1
InChiKey IZTPMTAWOCEKKM-VXMYZLRESA-N
MDL number MFCD00149309
Appearance White powder

References for Emetine dihydrochloride

References are publications that support the biological activity of the product

  • Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

    Choy et al (2020) Antiviral Res. 178 : 104786
    Read more (PubMedID: 32251767)

  • The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells

    Moeller et al (2007) Oncol Rep. 18(3) : 737-44
    Read more (PubMedID: 17671728)

  • Structural basis for inhibition of protein synthesis by emetine and cycloheximide based on an analogy between ipecac alkaloids and glutarimide antibiotics

    Grollman (1966) Proc Natl Acad Sci USA 56(6) : 1867-74
    Read more (PubMedID: 16591432)

3 Item(s)

Related Products
Grouped product items
Order: HB7389
Pack PriceQty
10mg
$39
50mg
$143
Protein synthesis inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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