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Emetine dihydrochloride

(HB7389)
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Product overview

Name Emetine dihydrochloride
Purity >98%
Description Protein synthesis inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description

Protein synthesis inhibitor with anti-protozoal effects. It binds to the ribosomal E site of Plasmodium falciparum to inhibit malaria.

Also shows antiviral effects against various RNA and DNA viruses including Zika and HIV-1). Also identified to inhibit hCoV-OC43, hCoV-NL43, SARS-CoV,MERS-CoV, and MHV-A59 in vitro with EC50 values reported at low micro-molar range and can effectively inhibit SARS-CoV-2 virus replication.

Solubility & Handling

Storage instructions Store at +4°C
Solubility overview Soluble in water
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name (2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4- tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10- dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido [2,1-a]isoquinoline dihydrochloride hydrate
Molecular Weight 480.64
Chemical structure Emetine [7083-71-8] Chemical Structure
Molecular Formula C29H40N2O4.2HCl
CAS Number 7083-71-8
PubChem identifier 201899
SMILES CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.O.Cl.Cl
InChi InChI=1S/C29H40N2O4.2ClH.H2O/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H;1H2/t18-,21-,24+,25-;;;/m0.../s1
InChiKey IZTPMTAWOCEKKM-VXMYZLRESA-N
MDL number MFCD00149309
Appearance White powder

References for Emetine dihydrochloride

References are publications that support the biological activity of the product

  • Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

    Choy et al (2020) Antiviral Res. 178 : 104786
    Read more (PubMedID: 32251767)

  • The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells

    Moeller et al (2007) Oncol Rep. 18(3) : 737-44
    Read more (PubMedID: 17671728)

  • Structural basis for inhibition of protein synthesis by emetine and cycloheximide based on an analogy between ipecac alkaloids and glutarimide antibiotics

    Grollman (1966) Proc Natl Acad Sci USA 56(6) : 1867-74
    Read more (PubMedID: 16591432)

3 Item(s)

Related Products
Grouped product items
Order: HB7389
Pack PriceQty
10mg
$39
50mg
$143
Protein synthesis inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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