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Lac-Phe

(HB8782)
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Technical documents: SDS CoA Datasheet
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Product overview

Name Lac-Phe
Alternative names N-l-lactoyl-Phe
Purity >99%
Description

Exercise induced metabolite that supresses food intake and obesity

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews (3) References (2) Frequently bought together
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Images

Lac-Phe (N-lactoyl-phenylalanine) product vial image | Hello Bio
Lac-Phe (N-lactoyl-phenylalanine) product vial image | Hello Bio

Lac-Phe (N-lactoyl-phenylalanine) product vial image | Hello Bio

Lac-Phe (N-lactoyl-phenylalanine) product vial image | Hello Bio

Biological Data

Biological description

L-lactate-derived metabolite which is upregulated following exercise. Recently shown to reduce food intake by ~50% in diet-induced obese (DIO) mice, without affecting movement or energy expenditure. Decreases body weight, adiposity and improves glucose homeostasis when chronically administered.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (50 mM), and in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name (2S)-2-[(2S)-2-hydroxypropanamido]-3-phenylpropanoic acid
Molecular Weight 237.3
Chemical structure Lac-Phe [183241-73-8] Chemical Structure
Molecular Formula C12H15NO4
CAS Number 183241-73-8
PubChem identifier 69759947
SMILES C[C@H](O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Source Synthetic
InChi InChI=1S/C12H15NO4/c1-8(14)11(15)13-10(12(16)17)7-9-5-3-2-4-6-9/h2-6,8,10,14H,7H2,1H3,(H,13,15)(H,16,17)/t8-,10-/m0/s1
Appearance White solid

References for Lac-Phe

References are publications that support the biological activity of the product

  • An exercise-inducible metabolite that suppresses feeding and obesity.

    Li VL et al (2022) Nature 606 : 785-790
    Read more (PubMedID: 35705806)

  • N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.

    Jansen RS et al (2015) Proceedings of the National Academy of Sciences of the United States of America 112 : 6601-6
    Read more (PubMedID: 25964343)

2 Item(s)

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Order: HB8782
Pack PriceQty
10mg
$87
50mg
$349
100mg
$628
10mM (add 1ml water)
$75
50mM (add 1ml water)
$141

Exercise induced metabolite that supresses food intake and obesity

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