First non-peptide selective orexin-1 (OX1) receptor antagonist which shows ~50-fold selectivity for OX1 over OX2 (pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing hOX1R and OX2R respectively).
Uses and applications
SB-334867 shows a variety of biological effects and has been used to investigate the role of OX1R in stress, obestiiy, drug addiction and relapse. It has been shown to reduce food intake and most active behaviours (eating, grooming, sniffing, locomotion and rearing), while increasing resting.
Solubility & Handling
Room temperature (desiccate)
Soluble in DMSO (100 mM), and in ethanol (10 mM with gentle warming). Do not add acid to any formulatin to aid solubilisation as this may cause the compound to undergo hydrolysis.
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use