First non-peptide selective orexin-1 (OX1) receptor antagonist which shows ~50-fold selectivity for OX1 over OX2 (pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing hOX1R and OX2R respectively).
Uses and applications
SB-334867 shows a variety of biological effects and has been used to investigate the role of OX1R in stress, obestiiy, drug addiction and relapse. It has been shown to reduce food intake and most active behaviours (eating, grooming, sniffing, locomotion and rearing), while increasing resting.
Solubility & Handling
Solubility overview
Soluble in DMSO (100 mM), and in ethanol (10 mM with gentle warming). Do not add acid to any formulatin to aid solubilisation as this may cause the compound to undergo hydrolysis.
Storage instructions
Room temperature (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
These publications cite the use of SB 334867 purchased from Hello Bio:
Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-related behaviours
Thomas et al (2020) bioRxiv : https://www.biorxiv.org/content/
![SB334867 [792173-99-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb2913_1.png "SB334867 [792173-99-0]")
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