Major N-terminal truncated metabolite of glucagon-like peptide GLP-1 (7-36), formed by dipeptidyl peptidase-IV (DPP IV) cleavage. Acts as human GLP-1 receptor antagonist to inhibit hepatic glucose production. Also acts as a weak insulinotropic agent.
Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor
Knudsen LB et al (1996) Eur J Pharmacol 318(2-3) : 429-35
Understanding purity and quality - a guide for life scientists
