Major N-terminal truncated metabolite of glucagon-like peptide GLP-1 (7-36), formed by dipeptidyl peptidase-IV (DPP IV) cleavage. Acts as human GLP-1 receptor antagonist to inhibit hepatic glucose production. Also acts as a weak insulinotropic agent.
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor
Knudsen LB et al (1996) Eur J Pharmacol 318(2-3) : 429-35
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