Product overview

Name GLP-1 (9-36) amide
Biological description

Major N-terminal truncated metabolite of glucagon-like peptide GLP-1 (7-36), formed by dipeptidyl peptidase-IV (DPP IV) cleavage. Acts as human GLP-1 receptor antagonist to inhibit hepatic glucose production. Also acts as a weak insulinotropic agent.

Purity >95%
Description

Major metabolite of GLP-1 (7-36)

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Solubility & Handling

Storage instructions -20°C
Solubility overview

Soluble in aqueous buffer

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Molecular Weight 3089.4
Molecular Formula C140H214N36O43
Sequence (one letter) EGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
Sequence (three letter) H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
Modifications C terminal amide
CAS Number 161748-29-4
PubChem identifier 90488821
InChiKey WPNGPBPCQMDAAD-WRFZDFFOSA-N

References for GLP-1 (9-36) amide

References are publications that support the biological activity of the product
  • Direct effects of exendin-(9,39) and GLP-1-(9,36)amide on insulin action, β-cell function, and glucose metabolism in nondiabetic subjects

    Sathananthan M et al (2013) Diabetes 62(8) : 2752-6
  • GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide

    Elahi D et al (2008) Obesity (Silver Spring) 16(7) : 1501-9
  • Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor

    Knudsen LB et al (1996) Eur J Pharmacol 318(2-3) : 429-35

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