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Orexin A (human, rat, mouse)

(HB2937)
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Technical documents: SDS CoA Datasheet
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Product overview

Name Orexin A (human, rat, mouse)
Biological description

Overview

Excitatory neuropeptide at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively).

Orexin-A is synthesized by a cluster of neurons in the lateral hypothalamus and perifornical area. Orexin A is composed of 33 amino acids.

Uses and applications

The peptide is involved in a variety of physiological functions. E.g. feeding behavior, sleep/wake rhythms, thermoregulation, energy metabolism and cardiovascular activity. More recently orexins have been suggested to have a role in emotional regulation, energetic homeostasis, reward mechanisms, drug addiction, arousal system, sleep and wakefulness.

Purity >95%
Description Excitatory neuropeptide at orexin OX1/OX2 receptors
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (2) References (3) Frequently bought together
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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More Info

Dilution

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More Info

Chemical Data

Purity >95%
Chemical name XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL (modifications: C-terminal amide; X-1 = Glp; Disulfide bonds: 6-12, 7-14)
Molecular Weight 3561.12
Chemical structure Orexin A (human, rat, mouse) | [205640-90-0] Chemical Structure
Molecular Formula C152H243N47O44S4
Sequence (one letter) XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL
Modifications C-terminal amide; X-1 = Glp; Disulfide bonds: 6-12, 7-14
CAS Number 205640-90-0
PubChem identifier 56842143
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]4CSSC[C@H]5C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N5)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CC(C)C)NC(=O)[C@@H]7CCCN7C(=O)[C@@H]8CCC(=O)N8)C(=O)N[C@H](C(=O)N4)CO)[C@@H](C)O)CCCCN)CCC(=O)N)CCCNC(=N)N
InChiKey OFNHNCAUVYOTPM-IIIOAANCSA-N
MDL number MFCD01635374

References for Orexin A (human, rat, mouse)

References are publications that support the biological activity of the product

3 Item(s)

Related Products
Grouped product items
Order: HB2937
Pack PriceQty
100μg
$147
500μg
$363
1mg
$491
Excitatory neuropeptide at orexin OX1/OX2 receptors
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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