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GsMTx4

(HB1161)
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Product overview

Name GsMTx4
Alternative names M-TRTx-Gr1a, M-theraphotoxin-Gr1a
Purity >95%
Description Piezo and TRP mechanosensitive channels inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (6) Frequently bought together
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Biological Data

Biological description

Gating modifier peptide from spider venom which selectively inhibits mechanosensitive ion channels such as Piezo and TRP.

It is commonly used in the study mechanosensitive channels function in physiology and pathology.

It has also recently been reported to inhibit a stretch-activated BK channel (SAKcaC) and TACAN, a mechanosensitive ion channel involved in pain regulation.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name H-Gly-DL-Cys(1)-DL-Leu-DL-Glu-DL-Phe-DL-Trp-DL-Trp-DL-Lys-DL-Cys(2)-DL-Asn-DL-Pro-DL-Asn-DL-Asp-DL-Asp-DL-Lys-DL-Cys(3)-DL-Cys(1)-DL-Arg-DL-Pro-DL-Lys-DL-Leu-DL-Lys-DL-Cys(2)-DL-Ser-DL-Lys-DL-Leu-DL-Phe-DL-Lys-DL-Leu-DL-Cys(3)-DL-Asn-DL-Phe-DL-Ser-DL-Phe-NH2
Molecular Weight 4095.86
Molecular Formula C185H273N49O45S6
CAS Number 1209500-46-8
PubChem identifier 90488987
SMILES [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
InChiKey WVDNTWXIIKNMHY-UHFFFAOYSA-N

References for GsMTx4

References are publications that support the biological activity of the product

  • Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology.

    Bowman CL et al (2007) Toxicon 49(2) : 249-70.
    Read more (PubMedID: 17157345)

Items 6 to 6 of 6 total

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Grouped product items
Order: HB1161
Pack PriceQty
100μg
$270
Piezo and TRP mechanosensitive channels inhibitor
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Hazardous: $35

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