Potent calcineurin phosphatase 2B (PP2B) inhibitor (IC50 = 2 nM). Interacts with FK-506 binding protein. Also inhibits IL-2 production by activated T-cells and reduces amount of GLUT4 on human adipocytes. Enhances osteoblastic differentiation in mesenchymal cells. Displays neuroprotective, antibiotic and immunosuppressant properties.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in ethanol (100 mM) and DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Cyclosporine A and Tacrolimus Reduce the Amount of GLUT4 at the Cell Surface in Human Adipocytes: Increased Endocytosis as a Potential Mechanism for the Diabetogenic Effects of Immunosuppressive Agents.
Pereira MJ et al (2014) J Clin Endocrinol Metab 99(10) : E1885-94.
Possible nitric oxide modulation in protective effect of FK-506 against 3-nitropropionic acid-induced behavioral, oxidative, neurochemical, and mitochondrial alterations in rat brain.
Kumar P et al (2010) Drug Chem Toxicol 33(4) : 377-92.
The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells.
Fruman DA et al (1995) J Immunol 154(4) : 1846-51.
Understanding purity and quality - a guide for life scientists
