Product overview
| Name | D-Serine |
| Description | NMDA receptor co-agonist |
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Biological Data
| Biological description | Endogenous NMDA receptor co-agonist. Binds at the glycine site with higher potency than glycine. Induces Ca2+-dependent inactivation of GluN2A subunit-containing NMDA receptors with potential neuroprotective effects. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (R)-2-amino-3-hydroxypropanoic acid |
| Molecular Weight | 105.09 |
| Chemical structure | ![D-Serine [312-84-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0267.png "D-Serine [312-84-5]") |
| Molecular Formula | C3H7NO3 |
| CAS Number | 312-84-5 |
| PubChem identifier | 71077 |
| SMILES | C([C@H](C(=O)O)N)O |
| InChi | InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1 |
| InChiKey | MTCFGRXMJLQNBG-UWTATZPHSA-N |
| MDL number | MFCD00004269 |
References for D-Serine
References are publications that support the biological activity of the product
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D-Serine-induced Inactivation of NMDA Receptors in Cultured Rat Hippocampal Neurons Expressing NR2A Subunits is Ca(2+) -Dependent.
Li X et al (2014) CNS Neurosci Ther 20(11) : 951-60. -
Long-term potentiation depends on release of D-serine from astrocytes.
Henneberger C et al (2010) Nature 463(7278) : 232-6. -
D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration.
Wolosker H et al (2008) FEBS J 275(14) : 3514-26.
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