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Biological Data

Biological description Endogenous NMDA receptor co-agonist. Binds at the glycine site with higher potency than glycine. Induces Ca2+-dependent inactivation of GluN2A subunit-containing NMDA receptors with potential neuroprotective effects.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name (R)-2-amino-3-hydroxypropanoic acid
Molecular Weight 105.09
Chemical structure D-Serine  [312-84-5] Chemical Structure
Molecular Formula C3H7NO3
CAS Number 312-84-5
PubChem identifier 71077
SMILES C([C@H](C(=O)O)N)O
InChi InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChiKey MTCFGRXMJLQNBG-UWTATZPHSA-N
MDL number MFCD00004269

References for D-Serine

References are publications that support the biological activity of the product
  • D-Serine-induced Inactivation of NMDA Receptors in Cultured Rat Hippocampal Neurons Expressing NR2A Subunits is Ca(2+) -Dependent.

    Li X et al (2014) CNS Neurosci Ther 20(11) : 951-60.
  • Long-term potentiation depends on release of D-serine from astrocytes.

    Henneberger C et al (2010) Nature 463(7278) : 232-6.
  • D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration.

    Wolosker H et al (2008) FEBS J 275(14) : 3514-26.