Competitive, non-transportable EAAT blocker (IC50 values are 70, 6 and 6 µM for EAAT1, EAAT2 and EAAT3 respectively and Ki values are 4.4 and 3.2 µM for EAAT4 and EAAT5. Selective for EAA transporters over ionotropic and metabotropic glutamate receptors. Inhibits glutamate uptake.
Solubility & Handling
Storage instructions
-20°C (desiccate)
Solubility overview
Soluble in DMSO (100mM, gentle warming) or water (5mM, gentle warming)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Neurotoxic and neuroprotective effects of the glutamate transporter inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) during physiological and ischemia-like conditions.
Bonde C et al (2003) Neurochem Int 43(4-5) : 371-80.
These publications cite the use of DL-TBOA purchased from Hello Bio:
Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuitBeltran-Matas et al
Beltran-Matas et al (2021) Eur J Neurosci. : 54(2)
![DL-TBOA [205309-81-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0258a.png "DL-TBOA [205309-81-5]")
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