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Images Ouabain product vial image | Hello Bio
Ouabain product vial image | Hello Bio Biological Data Biological description Selective Na+ / K+ ATPase inhibitor. Thought to act as a proliferative agent; promotes cardiac and vascular myocyte cell growth. Shows positive inotropic, vasoconstrictive and hypertensive actions.
Also shows antiviral activity (e.g. reported anti-MERS-CoV activity in Vero cells)
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (10mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
Chemical structure
Molecular Formula C29 H44 O12 .8H2 O
PubChem identifier 439501
SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@H]([C@@]3([C@@H]4[C@@H](CC[C@@]3(C2)O)[C@]5(CC[C@@H]([C@]5(C[C@H]4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O
InChi InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28
InChiKey LPMXVESGRSUGHW-HBYQJFLCSA-N
References for Ouabain References are publications that support the biological activity of the product
Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19 Ko et al (2020) bioRxiv : Preprint
Increased constrictor tone induced by ouabain treatment in rats. Pulgar VM et al (2013) J Cardiovasc Pharmacol 62(2) : 174-83. Effect of m-calpain in PKCalpha-mediated proliferation of pulmonary artery smooth muscle cells by low dose of ouabain. Shaikh S et al (2013) Indian J Biochem Biophys 50(5) : 419-27. Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy. Bai Y et al (2013) Am J Physiol Heart Circ Physiol 304(3) : H427-35.
Selective Na+ / K+ ATPase inhibitor. Shows antiviral activity.
![Ouabain [630-60-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1140.png "Ouabain [630-60-4]")
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