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Product overview

Alternative names DAGO
Purity >95%
Description Potent, selective μ-opioid receptor agonist
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DAMGO product vial image | Hello Bio

Biological Data

Biological description Potent, selective μ-opioid receptor agonist (Ki values are 2.0 and >1000 nM at μ, κ and δ respectively). Shows antinociceptive activity.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (4 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >95%
Chemical name H-Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol
Molecular Weight 513.7
Molecular Formula C26H35N5O6
CAS Number 78123-71-4
PubChem identifier 5462471
InChi InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
MDL number MFCD00133215

References for DAMGO

References are publications that support the biological activity of the product
  • The μ-opioid receptor agonist DAMGO presynaptically suppresses solitary tract-evoked input to neurons in the rostral solitary nucleus.

    Boxwell et al (2013) J Neurophysiol 109(11) : 2815-26
  • DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.

    Zhang et al (2013) Neuroscience 252 : 359-66
  • Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

    Raynor et al (1994) Mol Pharmacol 45(2) : 330-4

3 Item(s)

These publications cite the use of DAMGO purchased from Hello Bio:
  • Functional independence of endogenous μ-and δ-opioid receptors co-expressed in cholinergic interneurons

    Farrens et al (2021) bioRxiv https://doi.org/10.1101/2021.04.23.441175 : doi
  • A caged DAMGO for selective photoactivation of endogenous mu opioid receptors

    Banghart et al (2021) bioRxiv https://doi.org/10.1101/2021.09.13.460181 : doi
  • TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available μ-opioid receptor number

    Singleton S et al (2021) Br J Pharmacol 178(8) : 1855-1868
    PubMedID: 33555037
  • Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol

    Scarnati MS et al (2020) Alcohol 87 : 97-109
    PubMedID: 32561311
  • Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons

    Halikere A et al (2020) Mol Psychiatry 25(7) : 1406-1419
    PubMedID: 31481756

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