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Images DAMGO product vial image | Hello Bio
DAMGO product vial image | Hello Bio Biological Data Biological description Potent, selective μ-opioid receptor agonist (Ki values are 2.0 and >1000 nM at μ, κ and δ respectively). Shows antinociceptive activity.
Solubility & Handling Solubility overview Soluble in water (4 mM)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name H-Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol
Molecular Formula C26 H35 N5 O6
PubChem identifier 5462471
SMILES C[C@H](C(=O)NCC(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)NCCO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N
InChi InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
InChiKey HPZJMUBDEAMBFI-WTNAPCKOSA-N
References for DAMGO References are publications that support the biological activity of the product
The μ-opioid receptor agonist DAMGO presynaptically suppresses solitary tract-evoked input to neurons in the rostral solitary nucleus. Boxwell et al (2013) J Neurophysiol 109(11) : 2815-26 DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia. Zhang et al (2013) Neuroscience 252 : 359-66 Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Raynor et al (1994) Mol Pharmacol 45(2) : 330-4
Publications
These publications cite the use of DAMGO purchased from Hello Bio:
Functional independence of endogenous μ-and δ-opioid receptors co-expressed in cholinergic interneurons Farrens et al (2021) bioRxiv https://doi.org/10.1101/2021.04.23.441175 : doi
A caged DAMGO for selective photoactivation of endogenous mu opioid receptors Banghart et al (2021) bioRxiv https://doi.org/10.1101/2021.09.13.460181 : doi
TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available μ-opioid receptor number Singleton S et al (2021) Br J Pharmacol 178(8) : 1855-1868 Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol Scarnati MS et al (2020) Alcohol 87 : 97-109 Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons Halikere A et al (2020) Mol Psychiatry 25(7) : 1406-1419
Potent, selective μ-opioid receptor agonist
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