DAMGO

(HB2409)
Technical documents: SDS CoA Datasheet

Product overview

Name DAMGO
Description Potent, selective μ-opioid receptor agonist
Alternative names DAGO
Purity >95%
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Images

DAMGO product vial image | Hello Bio

Biological Data

Biological description Potent, selective μ-opioid receptor agonist (Ki values are 2.0 and >1000 nM at μ, κ and δ respectively). Shows antinociceptive activity.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (4 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name H-Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol
Molecular Weight 513.7
Molecular Formula C26H35N5O6
CAS Number 78123-71-4
PubChem identifier 5462471
SMILES C[C@H](C(=O)NCC(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)NCCO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N
InChi InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
InChiKey HPZJMUBDEAMBFI-WTNAPCKOSA-N
MDL number MFCD00133215

References for DAMGO

References are publications that support the biological activity of the product
  • The μ-opioid receptor agonist DAMGO presynaptically suppresses solitary tract-evoked input to neurons in the rostral solitary nucleus.

    Boxwell et al (2013) J Neurophysiol 109(11) : 2815-26
  • DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.

    Zhang et al (2013) Neuroscience 252 : 359-66
  • Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

    Raynor et al (1994) Mol Pharmacol 45(2) : 330-4
Publications
These publications cite the use of DAMGO purchased from Hello Bio:
  • Functional independence of endogenous μ-and δ-opioid receptors co-expressed in cholinergic interneurons

    Farrens et al (2021) bioRxiv https://doi.org/10.1101/2021.04.23.441175 : doi
  • A caged DAMGO for selective photoactivation of endogenous mu opioid receptors

    Banghart et al (2021) bioRxiv https://doi.org/10.1101/2021.09.13.460181 : doi
  • TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available μ-opioid receptor number

    Singleton S et al (2021) Br J Pharmacol 178(8) : 1855-1868
    PubMedID: 33555037
  • Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol

    Scarnati MS et al (2020) Alcohol 87 : 97-109
    PubMedID: 32561311
  • Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons

    Halikere A et al (2020) Mol Psychiatry 25(7) : 1406-1419
    PubMedID: 31481756

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