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Images
DAMGO product vial image | Hello Bio
DAMGO product vial image | Hello Bio
Biological Data
| Biological description | Potent, selective μ-opioid receptor agonist (Ki values are 2.0 and >1000 nM at μ, κ and δ respectively). Shows antinociceptive activity. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in water (4 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | H-Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol |
| Molecular Formula | C26H35N5O6 |
| PubChem identifier | 5462471 |
| SMILES | C[C@H](C(=O)NCC(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)NCCO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N |
| InChi | InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1 |
| InChiKey | HPZJMUBDEAMBFI-WTNAPCKOSA-N |
References for DAMGO
References are publications that support the biological activity of the product
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The μ-opioid receptor agonist DAMGO presynaptically suppresses solitary tract-evoked input to neurons in the rostral solitary nucleus.
Boxwell et al (2013) J Neurophysiol 109(11) : 2815-26 -
DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.
Zhang et al (2013) Neuroscience 252 : 359-66 -
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Raynor et al (1994) Mol Pharmacol 45(2) : 330-4
Publications
These publications cite the use of DAMGO purchased from Hello Bio:
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Functional independence of endogenous μ-and δ-opioid receptors co-expressed in cholinergic interneurons
Farrens et al (2021) bioRxiv https://doi.org/10.1101/2021.04.23.441175 : doi -
A caged DAMGO for selective photoactivation of endogenous mu opioid receptors
Banghart et al (2021) bioRxiv https://doi.org/10.1101/2021.09.13.460181 : doi -
TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available μ-opioid receptor number
Singleton S et al (2021) Br J Pharmacol 178(8) : 1855-1868 -
Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol
Scarnati MS et al (2020) Alcohol 87 : 97-109 -
Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons
Halikere A et al (2020) Mol Psychiatry 25(7) : 1406-1419
Potent, selective μ-opioid receptor agonist
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