Product overview
| Name | CIQ |
| Description | GluN2C / GluN2D subunit selective NMDA receptor positive allosteric modulator |
| Purity | >98% |
| Customer comments | We were happy with the CIQ indeed. Verified customer, University of Milan |
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Biological Data
| Biological description | GluN2C / GluN2D subunit selective NMDA receptor positive allosteric modulator. Causes two-fold increase in receptor channel opening frequency (EC50 values are 2.7 and 2.8 µM for GluN2C and GluN2D respectively). Reduces associated behaviours in schizophrenia models and potentially enhances DA release in Parkinson's disease models. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) and in ethanol (10mM, sonication) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone |
| Molecular Weight | 467.94 |
| Chemical structure | ![CIQ [486427-17-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0197.png "CIQ [486427-17-2]") |
| Molecular Formula | C26H26ClNO5 |
| CAS Number | 486427-17-2 |
| PubChem identifier | 4231127 |
| SMILES | COC1=CC=C(C=C1)OCC2C3=CC(=C(C=C3CCN2C(=O)C4=CC(=CC=C4)Cl)OC)OC |
| InChi | InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3 |
| InChiKey | VYMILMYEENZHAR-UHFFFAOYSA-N |
References for CIQ
References are publications that support the biological activity of the product
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Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dop release: implication for Parkinson's disease.
Zhang X et al (2014) Br J Pharmacol 171(16) : 3938-45. -
GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice.
Suryavanshi PS et al (2014) Br J Pharmacol 171(3) : 799-809. -
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.
Mullasseril P et al (2010) Nat Commun 1 : 90
Publications
These publications cite the use of CIQ purchased from Hello Bio:
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The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.
Sapkota et al (2019) Biochem Pharmacol 159 : 140-153PubMedID: 30503374 -
Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors
Yi F et al (2019) J Physiol 597(22) : 5495-5514PubMedID: 31541561
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