Technical documents: SDS Datasheet

Product overview

Name CIQ
Description GluN2C / GluN2D subunit selective NMDA receptor positive allosteric modulator
Purity >98%
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We were happy with the CIQ indeed. Verified customer, University of Milan

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CIQ: Scientist Approved

Biological Data

Biological description GluN2C / GluN2D subunit selective NMDA receptor positive allosteric modulator. Causes two-fold increase in receptor channel opening frequency (EC50 values are 2.7 and 2.8 µM for GluN2C and GluN2D respectively). Reduces associated behaviours in schizophrenia models and potentially enhances DA release in Parkinson's disease models.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) and in ethanol (10mM, sonication)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
Molecular Weight 467.94
Chemical structure CIQ  [486427-17-2] Chemical Structure
Molecular Formula C26H26ClNO5
CAS Number 486427-17-2
PubChem identifier 4231127
InChi InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3

References for CIQ

References are publications that support the biological activity of the product
  • Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dop release: implication for Parkinson's disease.

    Zhang X et al (2014) Br J Pharmacol 171(16) : 3938-45.
  • GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice.

    Suryavanshi PS et al (2014) Br J Pharmacol 171(3) : 799-809.
  • A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

    Mullasseril P et al (2010) Nat Commun 1 : 90
These publications cite the use of CIQ purchased from Hello Bio:
  • The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.

    Sapkota et al (2019) Biochem Pharmacol 159 : 140-153
    PubMedID: 30503374
  • Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors

    Yi F et al (2019) J Physiol 597(22) : 5495-5514
    PubMedID: 31541561

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